K+ channels as targets for specific immunomodulation

K. George Chandy, Heike Wulff, Christine Beeton, Michael Pennington, George A. Gutman, Michael D. Cahalan

Research output: Contribution to journalArticlepeer-review

355 Scopus citations

Abstract

The voltage-gated Kv1.3 channel and the Ca2+-activated IKCa1 K+ channel are expressed in T cells in a distinct pattern that depends on the state of lymphocyte activation and differentiation. The channel phenotype changes during the progression from the resting to the activated cell state and from naïve to effector memory cells, affording promise for specific immunomodulatory actions of K+ channel blockers. In this article, we review the functional roles of these channels in both naïve cells and memory cells, describe the development of selective inhibitors of Kv1.3 and IKCa1 channels, and provide a rationale for the potential therapeutic use of these inhibitors in immunological disorders.

Original languageEnglish (US)
Pages (from-to)280-289
Number of pages10
JournalTrends in Pharmacological Sciences
Volume25
Issue number5
DOIs
StatePublished - May 2004

ASJC Scopus subject areas

  • Pharmacology
  • Toxicology

Fingerprint Dive into the research topics of 'K<sup>+</sup> channels as targets for specific immunomodulation'. Together they form a unique fingerprint.

Cite this