Knoevenagel condensations of β-hemiacetyl esters

Pilho Kim, Marilyn M. Olmstead, Michael H. Nantz, Mark J. Kurth

Research output: Contribution to journalArticle

14 Scopus citations


The intermolecular Knoevenagel condensation of β-hemiacetyl ester proceeds by an in situ unmasking of a reactive ω-hydroxy-β-keto ester giving unsaturated ω-hydroxy-β-keto esters 6-12 which accommodate acetal formation. (C) 2000 Elsevier Science Ltd.

Original languageEnglish (US)
Pages (from-to)4029-4032
Number of pages4
JournalTetrahedron Letters
Issue number21
StatePublished - May 29 2000


  • Acetal formation
  • Eleuthesides
  • Knoevenagel condensation

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

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  • Cite this

    Kim, P., Olmstead, M. M., Nantz, M. H., & Kurth, M. J. (2000). Knoevenagel condensations of β-hemiacetyl esters. Tetrahedron Letters, 41(21), 4029-4032.