Klinefelter's syndrome and precocious puberty: A harbinger for tumor

Eric A Kurzrock, Hari Siva Gurunadha Rao Tunuguntla, Joseph E. Busby, Regina F Gandour-Edwards, Laurence A. Goldman

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Boys with Klinefelter's syndrome are at an increased risk of precocious puberty. Most cases are either idiopathic or due to a mediastinal tumor. Patients with Klinefelter's syndrome are at a high risk of primary, extragonadal germ cell tumors, which are usually nonseminomatous, but can be a mixed type with seminomatous elements. The differential diagnosis of precocious puberty includes mediastinal tumors, especially in boys with Klinefelter's syndrome.

Original languageEnglish (US)
JournalUrology
Volume60
Issue number3
StatePublished - Sep 2002

ASJC Scopus subject areas

  • Urology

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