Kinetic analysis of LDL apoB transport and metabolism in non-steady states

Andrzej Werýski, Zbigniew Nahorski, Bo Angelin, Lars Berglund, Mats Eriksson

Research output: Contribution to journalArticle

Abstract

In this paper a novel kinetic analysis is used for evaluation of the low density lipoprotein (LDL) apoB fractional catabolic rate (FCR) after LDL apheresis which creates a nonsteady state. The formulae for calculation of FCP. and LDL rate of appearance (Ra) as functions of time have been derived. Calculations for one normal and one familial hypercholesterolemic (FH) subjects showed that FCR as well as Ra exhibited variations which can be attributed to the circadian rhythm in LDL metabolism. LDL apheresis had a little impact on both Ra and FCR in normal as well as in FH subjects. However, Ra in FH subject was found to be much higher than that in the normal subject.

Original languageEnglish (US)
Pages (from-to)405-425
Number of pages21
JournalControl and Cybernetics
Volume29
Issue number1
StatePublished - 2000
Externally publishedYes

Keywords

  • Apheresis
  • Kinetic modelling
  • Low density lipoprotein (LDL)

ASJC Scopus subject areas

  • Control and Systems Engineering
  • Human-Computer Interaction

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  • Cite this

    Werýski, A., Nahorski, Z., Angelin, B., Berglund, L., & Eriksson, M. (2000). Kinetic analysis of LDL apoB transport and metabolism in non-steady states. Control and Cybernetics, 29(1), 405-425.