Kidney Transplantation Combined With Other Organs

Junichiro Sageshima, Linda Chen, Gaetano Ciancio, Alberto Pugliese, George W. Burke

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

In this chapter the addition of a kidney transplant to transplantation of other organs is described. The first section details the combination of pancreas with kidney transplantation for patients with diabetes mellitus and end-stage renal disease (ESRD). The next section describes the issues and controversies of adding a kidney transplant to a liver transplant. This centers on the difficulty in predicting which patients will experience recovery of kidney function. While the hepatorenal syndrome is reversible following liver transplantation, other causes of acute kidney injury, e.g., acute tubular necrosis and chronic kidney disease, are associated with significantly worse outcomes. The next section involves kidney transplantation after heart transplantation. The last section explores the influence that each organ may exert on the kidney transplant, and vice versa. There remains an important need to identify more reliable biomarkers to help differentiate reversible from irreversible kidney disease in the setting of end-stage liver and heart disease.

Original languageEnglish (US)
Title of host publicationKidney Transplantation, Bioengineering, and Regeneration
Subtitle of host publicationKidney Transplantation in the Regenerative Medicine Era
PublisherElsevier Inc.
Pages141-157
Number of pages17
ISBN (Electronic)9780128018361
ISBN (Print)9780128017340
DOIs
StatePublished - Jul 6 2017

Keywords

  • Acute kidney injury
  • Autoimmunity
  • Biomarkers
  • Heart transplant
  • Immunosuppression
  • Kidney transplant
  • Liver transplant
  • Pancreas transplant

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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  • Cite this

    Sageshima, J., Chen, L., Ciancio, G., Pugliese, A., & Burke, G. W. (2017). Kidney Transplantation Combined With Other Organs. In Kidney Transplantation, Bioengineering, and Regeneration: Kidney Transplantation in the Regenerative Medicine Era (pp. 141-157). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-801734-0.00012-6