Kidney cancer: Identification of novel targets for therapy

Robert H Weiss, P. Y. Lin

Research output: Contribution to journalArticle

105 Scopus citations

Abstract

Kidney cancer, although relatively rare when compared to other malignancies, occurs not uncommonly in patients with renal disease and is often discovered incidentally during the initial nephrologic work-up, or by the savvy clinician who is familiar with the paraneoplastic signs. While surgical approaches are generally curative when the disease is confined to the kidney, one-third of the cases that present in the metastatic form and require conventional medical therapy are associated with a truly dismal patient survival rate. In light of the emerging knowledge of the molecular mechanisms of kidney cancer oncogenesis, several novel and promising therapeutic approaches are emerging. In this review, we summarize the current state of kidney cancer diagnosis and therapy, as well as some of the novel treatments that capitalize on those newly elucidated molecular pathways that are deranged in this disease.

Original languageEnglish (US)
Pages (from-to)224-232
Number of pages9
JournalKidney International
Volume69
Issue number2
DOIs
StatePublished - Jan 2006

Keywords

  • Kidney cancer
  • Molecular targets
  • Therapy

ASJC Scopus subject areas

  • Nephrology

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