Ketosis Ameliorates Renal Cyst Growth in Polycystic Kidney Disease

Jacob A. Torres, Samantha L. Kruger, Caroline Broderick, Tselmeg Amarlkhagva, Shagun Agrawal, John R. Dodam, Michal Mrug, Leslie A. Lyons, Thomas Weimbs

Research output: Contribution to journalArticlepeer-review

38 Scopus citations


Dietary interventions that induce a state of ketosis were found to inhibit disease progression in animal models of polycystic kidney disease (PKD), a commonly inherited disease that leads to kidney failure. The beneficial effects of a ketogenic diet on PKD could be replicated in pre-clinical models by oral treatment with the natural ketone β-hydroxybutyrate.

Original languageEnglish (US)
Pages (from-to)1007-1023.e5
JournalCell Metabolism
Issue number6
StatePublished - Dec 3 2019
Externally publishedYes


  • beta-hydroxybutyrate
  • ketogenic diet
  • ketosis
  • metabolic inflexibility
  • polycystic kidney disease

ASJC Scopus subject areas

  • Physiology
  • Molecular Biology
  • Cell Biology


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