Ketosis Ameliorates Renal Cyst Growth in Polycystic Kidney Disease

Jacob A. Torres, Samantha L. Kruger, Caroline Broderick, Tselmeg Amarlkhagva, Shagun Agrawal, John R. Dodam, Michal Mrug, Leslie A. Lyons, Thomas Weimbs

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

Dietary interventions that induce a state of ketosis were found to inhibit disease progression in animal models of polycystic kidney disease (PKD), a commonly inherited disease that leads to kidney failure. The beneficial effects of a ketogenic diet on PKD could be replicated in pre-clinical models by oral treatment with the natural ketone β-hydroxybutyrate.

Original languageEnglish (US)
Pages (from-to)1007-1023.e5
JournalCell Metabolism
Volume30
Issue number6
DOIs
StatePublished - Dec 3 2019
Externally publishedYes

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Keywords

  • beta-hydroxybutyrate
  • ketogenic diet
  • ketosis
  • metabolic inflexibility
  • polycystic kidney disease

ASJC Scopus subject areas

  • Physiology
  • Molecular Biology
  • Cell Biology

Cite this

Torres, J. A., Kruger, S. L., Broderick, C., Amarlkhagva, T., Agrawal, S., Dodam, J. R., Mrug, M., Lyons, L. A., & Weimbs, T. (2019). Ketosis Ameliorates Renal Cyst Growth in Polycystic Kidney Disease. Cell Metabolism, 30(6), 1007-1023.e5. https://doi.org/10.1016/j.cmet.2019.09.012