Ketamine use in current clinical practice

Mei Gao, Damoon Rejaei, Hong Liu

Research output: Contribution to journalReview article

30 Citations (Scopus)

Abstract

After nearly half a century on the market, ketamine still occupies a unique corner in the medical armamentarium of anesthesiologists or clinicians treating pain. Over the last two decades, much research has been conducted highlighting the drug's mechanisms of action, specifically those of its enantiomers. Nowadays, ketamine is also being utilized for pediatric pain control in emergency department, with its anti-hyperalgesic and anti-inflammatory effects being revealed in acute and chronic pain management. Recently, new insights have been gained on ketamine's potential anti-depressive and antisuicidal effects. This article provides an overview of the drug's pharmacokinetics and pharmacodynamics while also discussing the potential benefits and risks of ketamine administration in various clinical settings.

Original languageEnglish (US)
Pages (from-to)865-872
Number of pages8
JournalActa Pharmacologica Sinica
Volume37
Issue number7
DOIs
StatePublished - Jul 1 2016

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Ketamine
Pain
Acute Pain
Pain Management
Chronic Pain
Pharmaceutical Preparations
Hospital Emergency Service
Anti-Inflammatory Agents
Pharmacokinetics
Pediatrics
Research

Keywords

  • anti-depressive medication
  • anti-inflammation
  • anti-suicidal effects
  • ketamine
  • pain management
  • pediatric caudal anesthesia

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

Cite this

Ketamine use in current clinical practice. / Gao, Mei; Rejaei, Damoon; Liu, Hong.

In: Acta Pharmacologica Sinica, Vol. 37, No. 7, 01.07.2016, p. 865-872.

Research output: Contribution to journalReview article

Gao, Mei ; Rejaei, Damoon ; Liu, Hong. / Ketamine use in current clinical practice. In: Acta Pharmacologica Sinica. 2016 ; Vol. 37, No. 7. pp. 865-872.
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