Keratoplasty: A historical perspective

Mark J Mannis, Jay H. Krachmer

Research output: Contribution to journalArticlepeer-review

22 Scopus citations


Replacement of the dysfunctional cornea was an idea originating in the 18th century. The 19th century was a period of intense experimentation with various forms of keratoplasty. This work bore fruits in the early 1900s when the successful penetrating homograft was realized. Since that time, advances in surgical techniques and methods of tissue preservation, as well as a greater appreciation of corneal immunobiology, have made keratoplasty a readily available surgical alternative.

Original languageEnglish (US)
Pages (from-to)333-338
Number of pages6
JournalSurvey of Ophthalmology
Issue number5
StatePublished - 1981
Externally publishedYes


  • anesthesia
  • asepsis
  • homograft
  • immunobiology
  • keratoplasty
  • trephine

ASJC Scopus subject areas

  • Ophthalmology


Dive into the research topics of 'Keratoplasty: A historical perspective'. Together they form a unique fingerprint.

Cite this