Keeping the blood flowing - Plasminogen activator genes and feeding behavior in vampire bats

Åsa Tellgren-Roth, Katharina Dittmar, Steven E. Massey, Cecilia Kemi, Christian Tellgren-Roth, Peter Savolainen, Leslie A Lyons, David A. Liberles

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

The blood feeding vampire bats emerged from New World leaf-nosed bats that fed on fruit and insects. Plasminogen activator, a serine protease that regulates blood coagulation, is known to be expressed in the saliva of Desmodus rotundus (common vampire bat) and is thought to be a key enzyme for the emergence of blood feeding in vampire bats. To better understand the evolution of this biological function, we studied the plasminogen activator (PA) genes from all vampire bat species in light of their feeding transition to bird and subsequently mammalian blood. We include the rare species Diphylla ecaudata and Diaemus youngi, where plasminogen activator had not previously been studied and demonstrate that PA gene duplication observed in Desmodus is not essential to the vampire phenotype, but relates to the emergence of predominant mammalian blood feeding in this species. Plasminogen activator has evolved through gene duplication, domain loss, and sequence evolution leading to change in fibrin-specificity and susceptibility to plasminogen activator inhibitor-1. Before undertaking this study, only the four plasminogen activator isoforms from Desmodus were known. The evolution of vampire bat plasminogen activators can now be linked phylogenetically to the transition in feeding behavior among vampire bat species from bird to mammalian blood.

Original languageEnglish (US)
Pages (from-to)39-47
Number of pages9
JournalNaturwissenschaften
Volume96
Issue number1
DOIs
StatePublished - Jan 2009

Fingerprint

plasminogen activator
feeding behavior
bat
Chiroptera
blood
Desmodus
hemophagy
gene
genes
gene duplication
eclosion
bird
blood coagulation
saliva
fibrin
birds
serine proteinases
rare species
coagulation
phenotype

Keywords

  • Domain evolution
  • Ecological niche
  • Gene duplication
  • Positive selection
  • Species adaptation

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics

Cite this

Tellgren-Roth, Å., Dittmar, K., Massey, S. E., Kemi, C., Tellgren-Roth, C., Savolainen, P., ... Liberles, D. A. (2009). Keeping the blood flowing - Plasminogen activator genes and feeding behavior in vampire bats. Naturwissenschaften, 96(1), 39-47. https://doi.org/10.1007/s00114-008-0446-0

Keeping the blood flowing - Plasminogen activator genes and feeding behavior in vampire bats. / Tellgren-Roth, Åsa; Dittmar, Katharina; Massey, Steven E.; Kemi, Cecilia; Tellgren-Roth, Christian; Savolainen, Peter; Lyons, Leslie A; Liberles, David A.

In: Naturwissenschaften, Vol. 96, No. 1, 01.2009, p. 39-47.

Research output: Contribution to journalArticle

Tellgren-Roth, Å, Dittmar, K, Massey, SE, Kemi, C, Tellgren-Roth, C, Savolainen, P, Lyons, LA & Liberles, DA 2009, 'Keeping the blood flowing - Plasminogen activator genes and feeding behavior in vampire bats', Naturwissenschaften, vol. 96, no. 1, pp. 39-47. https://doi.org/10.1007/s00114-008-0446-0
Tellgren-Roth Å, Dittmar K, Massey SE, Kemi C, Tellgren-Roth C, Savolainen P et al. Keeping the blood flowing - Plasminogen activator genes and feeding behavior in vampire bats. Naturwissenschaften. 2009 Jan;96(1):39-47. https://doi.org/10.1007/s00114-008-0446-0
Tellgren-Roth, Åsa ; Dittmar, Katharina ; Massey, Steven E. ; Kemi, Cecilia ; Tellgren-Roth, Christian ; Savolainen, Peter ; Lyons, Leslie A ; Liberles, David A. / Keeping the blood flowing - Plasminogen activator genes and feeding behavior in vampire bats. In: Naturwissenschaften. 2009 ; Vol. 96, No. 1. pp. 39-47.
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