Abstract
Kawasaki Disease, a systemic vasculitis of unknown origin with specific predilection for the coronary arteries, is the most common cause of childhood-acquired heart disease in western countries. Despite its world-wide incidence, the pathophysiology of this enigmatic disease is still under investigation. Diagnosis is made on a clinical basis, with supportive laboratory evidence and imaging. Once identified, timely initiation of treatment is imperative in order to quell the inflammatory response and decrease the incidence of long-term sequelae, specifically coronary artery aneurysms. Finally, longitudinal follow-up should be implemented based on risk stratification and individualized to each patient.
| Original language | English (US) |
|---|---|
| Article number | 423 |
| Journal | Current Rheumatology Reports |
| Volume | 16 |
| Issue number | 6 |
| DOIs | |
| State | Published - Jan 1 2014 |
| Externally published | Yes |
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Keywords
- Aneurysm
- Clinical manifestations
- Coronary artery
- Corticosteroids
- Diagnosis
- Etiology
- Immunoglobulin
- IVIg resistance
- Kawasaki disease
- Management
- Pathophysiology
- Treatment
- Vasculitis
ASJC Scopus subject areas
- Rheumatology
Cite this
Kawasaki disease : Pathophysiology, clinical manifestations, and management. / Dimitriades, Victoria; Brown, Amanda G.; Gedalia, Abraham.
In: Current Rheumatology Reports, Vol. 16, No. 6, 423, 01.01.2014.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Kawasaki disease
T2 - Pathophysiology, clinical manifestations, and management
AU - Dimitriades, Victoria
AU - Brown, Amanda G.
AU - Gedalia, Abraham
PY - 2014/1/1
Y1 - 2014/1/1
N2 - Kawasaki Disease, a systemic vasculitis of unknown origin with specific predilection for the coronary arteries, is the most common cause of childhood-acquired heart disease in western countries. Despite its world-wide incidence, the pathophysiology of this enigmatic disease is still under investigation. Diagnosis is made on a clinical basis, with supportive laboratory evidence and imaging. Once identified, timely initiation of treatment is imperative in order to quell the inflammatory response and decrease the incidence of long-term sequelae, specifically coronary artery aneurysms. Finally, longitudinal follow-up should be implemented based on risk stratification and individualized to each patient.
AB - Kawasaki Disease, a systemic vasculitis of unknown origin with specific predilection for the coronary arteries, is the most common cause of childhood-acquired heart disease in western countries. Despite its world-wide incidence, the pathophysiology of this enigmatic disease is still under investigation. Diagnosis is made on a clinical basis, with supportive laboratory evidence and imaging. Once identified, timely initiation of treatment is imperative in order to quell the inflammatory response and decrease the incidence of long-term sequelae, specifically coronary artery aneurysms. Finally, longitudinal follow-up should be implemented based on risk stratification and individualized to each patient.
KW - Aneurysm
KW - Clinical manifestations
KW - Coronary artery
KW - Corticosteroids
KW - Diagnosis
KW - Etiology
KW - Immunoglobulin
KW - IVIg resistance
KW - Kawasaki disease
KW - Management
KW - Pathophysiology
KW - Treatment
KW - Vasculitis
UR - http://www.scopus.com/inward/record.url?scp=84899675637&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84899675637&partnerID=8YFLogxK
U2 - 10.1007/s11926-014-0423-x
DO - 10.1007/s11926-014-0423-x
M3 - Review article
C2 - 24744086
AN - SCOPUS:84899675637
VL - 16
JO - Current Rheumatology Reports
JF - Current Rheumatology Reports
SN - 1523-3774
IS - 6
M1 - 423
ER -