Kawasaki disease: Pathophysiology, clinical manifestations, and management

Victoria Dimitriades, Amanda G. Brown, Abraham Gedalia

Research output: Contribution to journalReview article

29 Scopus citations

Abstract

Kawasaki Disease, a systemic vasculitis of unknown origin with specific predilection for the coronary arteries, is the most common cause of childhood-acquired heart disease in western countries. Despite its world-wide incidence, the pathophysiology of this enigmatic disease is still under investigation. Diagnosis is made on a clinical basis, with supportive laboratory evidence and imaging. Once identified, timely initiation of treatment is imperative in order to quell the inflammatory response and decrease the incidence of long-term sequelae, specifically coronary artery aneurysms. Finally, longitudinal follow-up should be implemented based on risk stratification and individualized to each patient.

Original languageEnglish (US)
Article number423
JournalCurrent Rheumatology Reports
Volume16
Issue number6
DOIs
StatePublished - Jan 1 2014
Externally publishedYes

Keywords

  • Aneurysm
  • Clinical manifestations
  • Coronary artery
  • Corticosteroids
  • Diagnosis
  • Etiology
  • Immunoglobulin
  • IVIg resistance
  • Kawasaki disease
  • Management
  • Pathophysiology
  • Treatment
  • Vasculitis

ASJC Scopus subject areas

  • Rheumatology

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