Abstract
Kawasaki Disease, a systemic vasculitis of unknown origin with specific predilection for the coronary arteries, is the most common cause of childhood-acquired heart disease in western countries. Despite its world-wide incidence, the pathophysiology of this enigmatic disease is still under investigation. Diagnosis is made on a clinical basis, with supportive laboratory evidence and imaging. Once identified, timely initiation of treatment is imperative in order to quell the inflammatory response and decrease the incidence of long-term sequelae, specifically coronary artery aneurysms. Finally, longitudinal follow-up should be implemented based on risk stratification and individualized to each patient.
Original language | English (US) |
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Article number | 423 |
Journal | Current Rheumatology Reports |
Volume | 16 |
Issue number | 6 |
DOIs | |
State | Published - Jan 1 2014 |
Externally published | Yes |
Keywords
- Aneurysm
- Clinical manifestations
- Coronary artery
- Corticosteroids
- Diagnosis
- Etiology
- Immunoglobulin
- IVIg resistance
- Kawasaki disease
- Management
- Pathophysiology
- Treatment
- Vasculitis
ASJC Scopus subject areas
- Rheumatology