Kaposi’s sarcoma in an hiv-negative patient

We report an HIV-negative, 55-year-old man with recurrent Kaposi’s sarcoma (KS) of the lower extremities, who does not fit into any of the four previously described variants of KS: classic KS, AIDS-related KS, iatrogenic KS, and Africanendemic KS. There are reports in the literature of childhood-onset KS, which is thought to be due to an inherited immune deficiency that confers a higher susceptibility to human Herpesvirus-8 (HHV- 8), which is the virus that is known to cause KS. Our patient may be affected with an inherited immune deficiency that has predisposed him to KS, and this mutation also may account for his prostate and bladder cancer.