Abstract
In mammalian cells, multiple cellular processes, including gene silencing, cell growth and differentiation, pluripotency, neoplastic transformation, apoptosis, DNA repair, and maintenance of genomic integrity, converge on the evolutionarily conserved protein KAP1, which is thought to regulate the dynamic organization of chromatin structure via its ability to influence epigenetic patterns and chromatin compaction. In this minireview, we discuss how KAP1 might execute such pleiotropic effects, focusing on genomic targeting mechanisms, protein-protein interactions, specific post-translational modifications of both KAP1 and associated histones, and transcriptome analyses of cells deficient in KAP1.
Original language | English (US) |
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Pages (from-to) | 26267-26276 |
Number of pages | 10 |
Journal | Journal of Biological Chemistry |
Volume | 286 |
Issue number | 30 |
DOIs | |
State | Published - Jul 29 2011 |
Externally published | Yes |
ASJC Scopus subject areas
- Biochemistry
- Cell Biology
- Molecular Biology