Abstract
In mammalian cells, multiple cellular processes, including gene silencing, cell growth and differentiation, pluripotency, neoplastic transformation, apoptosis, DNA repair, and maintenance of genomic integrity, converge on the evolutionarily conserved protein KAP1, which is thought to regulate the dynamic organization of chromatin structure via its ability to influence epigenetic patterns and chromatin compaction. In this minireview, we discuss how KAP1 might execute such pleiotropic effects, focusing on genomic targeting mechanisms, protein-protein interactions, specific post-translational modifications of both KAP1 and associated histones, and transcriptome analyses of cells deficient in KAP1.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 26267-26276 |
| Number of pages | 10 |
| Journal | Journal of Biological Chemistry |
| Volume | 286 |
| Issue number | 30 |
| DOIs | |
| State | Published - Jul 29 2011 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Biochemistry
- Cell Biology
- Molecular Biology
Cite this
KAP1 protein : An enigmatic master regulator of the genome. / Iyengar, Sushma; Farnham, Peggy J.
In: Journal of Biological Chemistry, Vol. 286, No. 30, 29.07.2011, p. 26267-26276.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - KAP1 protein
T2 - An enigmatic master regulator of the genome
AU - Iyengar, Sushma
AU - Farnham, Peggy J.
PY - 2011/7/29
Y1 - 2011/7/29
N2 - In mammalian cells, multiple cellular processes, including gene silencing, cell growth and differentiation, pluripotency, neoplastic transformation, apoptosis, DNA repair, and maintenance of genomic integrity, converge on the evolutionarily conserved protein KAP1, which is thought to regulate the dynamic organization of chromatin structure via its ability to influence epigenetic patterns and chromatin compaction. In this minireview, we discuss how KAP1 might execute such pleiotropic effects, focusing on genomic targeting mechanisms, protein-protein interactions, specific post-translational modifications of both KAP1 and associated histones, and transcriptome analyses of cells deficient in KAP1.
AB - In mammalian cells, multiple cellular processes, including gene silencing, cell growth and differentiation, pluripotency, neoplastic transformation, apoptosis, DNA repair, and maintenance of genomic integrity, converge on the evolutionarily conserved protein KAP1, which is thought to regulate the dynamic organization of chromatin structure via its ability to influence epigenetic patterns and chromatin compaction. In this minireview, we discuss how KAP1 might execute such pleiotropic effects, focusing on genomic targeting mechanisms, protein-protein interactions, specific post-translational modifications of both KAP1 and associated histones, and transcriptome analyses of cells deficient in KAP1.
UR - http://www.scopus.com/inward/record.url?scp=79960677839&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79960677839&partnerID=8YFLogxK
U2 - 10.1074/jbc.R111.252569
DO - 10.1074/jbc.R111.252569
M3 - Article
C2 - 21652716
AN - SCOPUS:79960677839
VL - 286
SP - 26267
EP - 26276
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
SN - 0021-9258
IS - 30
ER -