Kainate receptor-mediated heterosynaptic facilitation in the amygdala

He Li, Aiqin Chen, Guoqiang Xing, Mei Ling Wei, Michael A Rogawski

Research output: Contribution to journalArticle

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Abstract

Prolonged low-frequency stimulation of excitatory afferents to basolateral amygdala neurons results in enduring enhancement of excitatory synaptic responses. The induction of this form of synaptic plasticity is eliminated by selective antagonists of GluR5 kainate receptors and can be mimicked by the GluR5 agonist ATPA. Kainate receptor-mediated synaptic facilitation generalizes to include inactive afferent synapses on the target neurons, and therefore contrasts with other types of activity-dependent enduring synaptic facilitation that are input-pathway specific. Such heterosynaptic spread of synaptic facilitation could account for adaptive and pathological expansion in the set of critical internal and external stimuli that trigger amygdala-dependent behavioral responses.

Original languageEnglish (US)
Pages (from-to)612-620
Number of pages9
JournalNature Neuroscience
Volume4
Issue number6
DOIs
StatePublished - 2001
Externally publishedYes

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ASJC Scopus subject areas

  • Neuroscience(all)

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