Abstract
Background: Epilepsy is relatively uncommon in horses compared with other species and limited information is available. Hypothesis: The objectives of the study were to describe the age of onset, clinical signs, clinicopathologic data, electroencephalographic findings, treatment, and outcome, including long-term prognosis in Arabian foals with idiopathic epilepsy. Animals: Twenty-two foals were included in the study. Materials and Methods: Medical records from 1985 to 2005 were reviewed. Results: The age of onset of affected foals ranged from 2 days to 6 months. Seizures were characterized by generalized tonic and clonic motor activity, staring, and loss of consciousness. The most common postictal signs were transient blindness and abnormal mental status. The interictal neurologic examination was otherwise normal. Clinicopathologic data and imaging diagnostics were normal except in 4 foals that developed complications. Electroencephalography revealed epileptiform activity in 9 of 13 foals. Foals were treated with benzodiazepines for the short-term; whereas phenobarbital was used over the long-term. Potassium bromide was added in 3 foals in which seizures were multiple, frequent, and difficult to control. The long-term prognosis was favorable with cessation of seizures by 1 year of age. The most common complication was head trauma. The most common concurrent disease was pneumonia. Conclusions and Clinical Importance: Juvenile idiopathic epilepsy of Egyptian Arabian foals has an early clinical onset but appears to be self-limiting. Information obtained from this study strongly suggests a heritable condition that merits further investigation.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1443-1449 |
| Number of pages | 7 |
| Journal | Journal of Veterinary Internal Medicine |
| Volume | 20 |
| Issue number | 6 |
| DOIs | |
| State | Published - Nov 2006 |
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Keywords
- Arabian foals
- Electroencephalography
- Epilepsy
- Phenobarbital
- Potassium bromide
ASJC Scopus subject areas
- veterinary(all)
Cite this
Juvenile idiopathic epilepsy in Egyptian Arabian foals : 22 Cases (1985-2005). / Aleman, Monica R; Gray, Leah C.; Williams, D. Colette; Holliday, Terrell A.; Madigan, John E; Lecouteur, Richard A; Magdesian, K G.
In: Journal of Veterinary Internal Medicine, Vol. 20, No. 6, 11.2006, p. 1443-1449.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Juvenile idiopathic epilepsy in Egyptian Arabian foals
T2 - 22 Cases (1985-2005)
AU - Aleman, Monica R
AU - Gray, Leah C.
AU - Williams, D. Colette
AU - Holliday, Terrell A.
AU - Madigan, John E
AU - Lecouteur, Richard A
AU - Magdesian, K G
PY - 2006/11
Y1 - 2006/11
N2 - Background: Epilepsy is relatively uncommon in horses compared with other species and limited information is available. Hypothesis: The objectives of the study were to describe the age of onset, clinical signs, clinicopathologic data, electroencephalographic findings, treatment, and outcome, including long-term prognosis in Arabian foals with idiopathic epilepsy. Animals: Twenty-two foals were included in the study. Materials and Methods: Medical records from 1985 to 2005 were reviewed. Results: The age of onset of affected foals ranged from 2 days to 6 months. Seizures were characterized by generalized tonic and clonic motor activity, staring, and loss of consciousness. The most common postictal signs were transient blindness and abnormal mental status. The interictal neurologic examination was otherwise normal. Clinicopathologic data and imaging diagnostics were normal except in 4 foals that developed complications. Electroencephalography revealed epileptiform activity in 9 of 13 foals. Foals were treated with benzodiazepines for the short-term; whereas phenobarbital was used over the long-term. Potassium bromide was added in 3 foals in which seizures were multiple, frequent, and difficult to control. The long-term prognosis was favorable with cessation of seizures by 1 year of age. The most common complication was head trauma. The most common concurrent disease was pneumonia. Conclusions and Clinical Importance: Juvenile idiopathic epilepsy of Egyptian Arabian foals has an early clinical onset but appears to be self-limiting. Information obtained from this study strongly suggests a heritable condition that merits further investigation.
AB - Background: Epilepsy is relatively uncommon in horses compared with other species and limited information is available. Hypothesis: The objectives of the study were to describe the age of onset, clinical signs, clinicopathologic data, electroencephalographic findings, treatment, and outcome, including long-term prognosis in Arabian foals with idiopathic epilepsy. Animals: Twenty-two foals were included in the study. Materials and Methods: Medical records from 1985 to 2005 were reviewed. Results: The age of onset of affected foals ranged from 2 days to 6 months. Seizures were characterized by generalized tonic and clonic motor activity, staring, and loss of consciousness. The most common postictal signs were transient blindness and abnormal mental status. The interictal neurologic examination was otherwise normal. Clinicopathologic data and imaging diagnostics were normal except in 4 foals that developed complications. Electroencephalography revealed epileptiform activity in 9 of 13 foals. Foals were treated with benzodiazepines for the short-term; whereas phenobarbital was used over the long-term. Potassium bromide was added in 3 foals in which seizures were multiple, frequent, and difficult to control. The long-term prognosis was favorable with cessation of seizures by 1 year of age. The most common complication was head trauma. The most common concurrent disease was pneumonia. Conclusions and Clinical Importance: Juvenile idiopathic epilepsy of Egyptian Arabian foals has an early clinical onset but appears to be self-limiting. Information obtained from this study strongly suggests a heritable condition that merits further investigation.
KW - Arabian foals
KW - Electroencephalography
KW - Epilepsy
KW - Phenobarbital
KW - Potassium bromide
UR - http://www.scopus.com/inward/record.url?scp=33845712787&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33845712787&partnerID=8YFLogxK
U2 - 10.1892/0891-6640(2006)20[1443:JIEIEA]2.0.CO;2
DO - 10.1892/0891-6640(2006)20[1443:JIEIEA]2.0.CO;2
M3 - Article
C2 - 17186863
AN - SCOPUS:33845712787
VL - 20
SP - 1443
EP - 1449
JO - Journal of Veterinary Internal Medicine
JF - Journal of Veterinary Internal Medicine
SN - 0891-6640
IS - 6
ER -