Juvenile idiopathic arthritis

Andrea T. Borchers, Carlo Selmi, Gurtej S. Cheema, Carl L Keen, Yehuda Shoenfeld, M. Eric Gershwin

Research output: Contribution to journalArticle

84 Citations (Scopus)

Abstract

One of the most enigmatic problems in rheumatology has been juvenile idiopathic arthritis (JIA). Firstly, the classification has often depended on clinical features that have variations between patients. Secondly, there are different classification schemes in usage and there are few objective serologic tests that help to resolve the differences between the criteria sets. Thirdly, only recently have significant advances been made in understanding the immunology and immunopathology of JIA and, in particular, new treatment options. In this review, we will define the historical basis of JIA and emphasize not only the clinical features, but also the immunological characteristics, the pathogenesis, and treatment options. We will also discuss, in particular, quality of life, psychosocial functioning, socioeconomic outcomes and the difficult area of mortality. Finally, this review will attempt to bridge genetic observations with clinical presentation. JIA represents a relatively common syndrome of pediatric onset rheumatologic disease and a better understanding of the clinical definition, the relationship to autoimmunity, and novel treatments with biologic agents are critical for improved patient care.

Original languageEnglish (US)
Pages (from-to)279-298
Number of pages20
JournalAutoimmunity Reviews
Volume5
Issue number4
DOIs
StatePublished - Apr 2006

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Juvenile Arthritis
Biological Factors
Rheumatology
Serologic Tests
Allergy and Immunology
Autoimmunity
Patient Care
Therapeutics
Quality of Life
Pediatrics
Mortality

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

Juvenile idiopathic arthritis. / Borchers, Andrea T.; Selmi, Carlo; Cheema, Gurtej S.; Keen, Carl L; Shoenfeld, Yehuda; Gershwin, M. Eric.

In: Autoimmunity Reviews, Vol. 5, No. 4, 04.2006, p. 279-298.

Research output: Contribution to journalArticle

Borchers, AT, Selmi, C, Cheema, GS, Keen, CL, Shoenfeld, Y & Gershwin, ME 2006, 'Juvenile idiopathic arthritis', Autoimmunity Reviews, vol. 5, no. 4, pp. 279-298. https://doi.org/10.1016/j.autrev.2005.09.011
Borchers, Andrea T. ; Selmi, Carlo ; Cheema, Gurtej S. ; Keen, Carl L ; Shoenfeld, Yehuda ; Gershwin, M. Eric. / Juvenile idiopathic arthritis. In: Autoimmunity Reviews. 2006 ; Vol. 5, No. 4. pp. 279-298.
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