TY - JOUR
T1 - Joint-adjacent Adipose Tissue by MRI is Associated With Prevalence and Progression of Knee Degenerative Changes
T2 - Data from the Osteoarthritis Initiative
AU - Bodden, Jannis
AU - Ok, Ahmet H.
AU - Joseph, Gabby B.
AU - Nevitt, Michael C.
AU - McCulloch, Charles E.
AU - Lane, Nancy E.
AU - Link, Thomas M.
N1 - Funding Information:
The analyses in this study were funded through NIH/NIAMS (National Institute of Arthritis and Musculoskeletal and Skin Diseases grant R01AR064771). The study was supported by the Osteoarthritis Initiative, a public–private partnership comprising 5 NIH contracts (National Institute of Arthritis and Musculoskeletal and Skin Diseases contracts N01‐AR‐2‐2258, N01‐AR‐2‐2259, N01‐AR‐2‐2260, N01‐AR‐2‐2261, and N01‐AR‐2‐2262), with research conducted by the Osteoarthritis Initiative Study Investigators. The study was also funded in part by the Intramural Research Program of the National Institute on Aging, NIH. Private funding partners include Merck Research, Novartis Pharmaceuticals, GlaxoSmithKline, and Pfizer; the private sector funding for the Osteoarthritis Initiative is managed by the Foundation for the National Institutes of Health. This manuscript was prepared using an OAI public use data set and does not necessarily reflect the opinions or views of the OAI investigators, the NIH, or the private funding partners.
Publisher Copyright:
© 2021 The Authors. Journal of Magnetic Resonance Imaging published by Wiley Periodicals LLC. on behalf of International Society for Magnetic Resonance in Medicine.
Copyright:
Copyright 2021 Elsevier B.V., All rights reserved.
PY - 2021
Y1 - 2021
N2 - Background: Adipose tissue has recently gained interest as an independent imaging biomarker for osteoarthritis. Purpose: To explore 1) cross-sectional associations between local subcutaneous fat (SCF) thickness at the knee and the extent of degenerative changes in overweight and obese individuals and 2) associations between local fat distribution and progression of osteoarthritis over 4 years. Study Type: Retrospective cohort study. Population: 338 obese and overweight participants from the Osteoarthritis Initiative cohort without radiographic evidence of osteoarthritis. Field Strength: 3T: 3D-FLASH-WE; 3D-DESS-WE; T1w-SE; MSME. Assessment: Baseline SCF thickness was measured in standardized locations medial, lateral and anterior to the knee and the average joint-adjacent SCF (ajSCF) was calculated. Right thigh SCF cross-sectional area was assessed. Quantitative cartilage T2 relaxation times and semi-quantitative whole organ MRI scores (WORMS) were obtained at baseline and 4-year follow-up. WORMSsum was calculated as sum of cartilage, bone marrow edema, subchondral cyst, and meniscal scores. Statistical Tests: Associations of SCF measures with baseline, and 4-year change in T2 and WORMS were analyzed using regression models. SCF measurements were standardized using the equation (Formula presented.). Analyses were adjusted for age, sex, physical activity, and BMI. Results: Cross-sectionally, significant associations between lateral SCF, lateral compartment WORMS and T2 were found ((Formula presented.), [95% CI]: 0.53, [0.12–0.95], P < 0.05; ΔT2: 0.50, [0.02–0.98], P < 0.05). Moreover, greater lateral SCF was associated with faster progression of lateral WORMSsum gradings (OR = 1.50, [1.05–2.15], P < 0.05). No significant positive associations were found for thigh SCF and WORMSsum (P = 0.44) or T2 measurements (medial: P = 0.15, lateral: 0.39, patellar: P = 0.75). Data Conclusion: Joint-adjacent SCF thickness was associated with imaging parameters of knee osteoarthritis, both cross-sectionally and longitudinally, while thigh SCF was not, suggesting a spatial association of SCF and knee osteoarthritis. Based on these findings, joint-adjacent SCF may play a role in the development and progression of knee osteoarthritis. Level of Evidence: 4. Technical Efficacy: Stage 5.
AB - Background: Adipose tissue has recently gained interest as an independent imaging biomarker for osteoarthritis. Purpose: To explore 1) cross-sectional associations between local subcutaneous fat (SCF) thickness at the knee and the extent of degenerative changes in overweight and obese individuals and 2) associations between local fat distribution and progression of osteoarthritis over 4 years. Study Type: Retrospective cohort study. Population: 338 obese and overweight participants from the Osteoarthritis Initiative cohort without radiographic evidence of osteoarthritis. Field Strength: 3T: 3D-FLASH-WE; 3D-DESS-WE; T1w-SE; MSME. Assessment: Baseline SCF thickness was measured in standardized locations medial, lateral and anterior to the knee and the average joint-adjacent SCF (ajSCF) was calculated. Right thigh SCF cross-sectional area was assessed. Quantitative cartilage T2 relaxation times and semi-quantitative whole organ MRI scores (WORMS) were obtained at baseline and 4-year follow-up. WORMSsum was calculated as sum of cartilage, bone marrow edema, subchondral cyst, and meniscal scores. Statistical Tests: Associations of SCF measures with baseline, and 4-year change in T2 and WORMS were analyzed using regression models. SCF measurements were standardized using the equation (Formula presented.). Analyses were adjusted for age, sex, physical activity, and BMI. Results: Cross-sectionally, significant associations between lateral SCF, lateral compartment WORMS and T2 were found ((Formula presented.), [95% CI]: 0.53, [0.12–0.95], P < 0.05; ΔT2: 0.50, [0.02–0.98], P < 0.05). Moreover, greater lateral SCF was associated with faster progression of lateral WORMSsum gradings (OR = 1.50, [1.05–2.15], P < 0.05). No significant positive associations were found for thigh SCF and WORMSsum (P = 0.44) or T2 measurements (medial: P = 0.15, lateral: 0.39, patellar: P = 0.75). Data Conclusion: Joint-adjacent SCF thickness was associated with imaging parameters of knee osteoarthritis, both cross-sectionally and longitudinally, while thigh SCF was not, suggesting a spatial association of SCF and knee osteoarthritis. Based on these findings, joint-adjacent SCF may play a role in the development and progression of knee osteoarthritis. Level of Evidence: 4. Technical Efficacy: Stage 5.
KW - knee
KW - osteoarthritis
KW - osteoarthritis initiative
KW - quantitative imaging biomarker
KW - T2 relaxation time
UR - http://www.scopus.com/inward/record.url?scp=85101860156&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85101860156&partnerID=8YFLogxK
U2 - 10.1002/jmri.27574
DO - 10.1002/jmri.27574
M3 - Article
C2 - 33644919
AN - SCOPUS:85101860156
JO - Journal of Magnetic Resonance Imaging
JF - Journal of Magnetic Resonance Imaging
SN - 1053-1807
ER -