Johne's disease in a free-ranging white-tailed deer from virginia and subsequent surveillance for mycobacterium avium subspecies paratuberculosis

Jonathan M. Sleeman, Elizabeth J B Manning, John H. Rohm, Jerry P. Sims, Susan Sanchez, Richard W. Gerhold, Michael K Keel

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Johne's disease (paratuberculosis) was diagnosed in a 2-yr-old, male, free-ranging white-tailed deer (Odocoileus virginianus) from Fauquier County, Virginia, USA, based on histopathology and culture for Mycobacterium avium subspecies paratuberculosis. Clinical and pathologic findings included emaciation; loss of body fat; chronic diarrhea; severe, chronic, diffuse granulomatous colitis with intrahistiocytic acid-fast bacilli; moderate, chronic granulomatous lymphadenitis with intrahistiocytic acid-fast bacilli; as well as moderate chronic, multifocal, lymphoplasmacytic hepatitis. These findings are consistent with previous reports of Johne's disease in cervids. Subsequent targeted surveillance of 10 emaciated deer with diarrhea, as well as sampling of 72 asymptomatic deer for M. avium subsp. paratuberculosis using culture of multiple tissue types, as well as serology using an. enzyme-linked immunosorbent assay (ELISA) optimized for cervid antibody detection, did not reveal any additional cases of infection in this geographic region. To date, this appears to be an isolated case of Johne's disease in a freeranging white-tailed deer, and infection with the causative agent for Johne's disease appears to be an infrequent occurrence in deer from this region. The origin of infection was most likely domestic ruminants. This is the first report of clinical Johne's disease in a freeranging white-tailed deer outside of the Florida Keys, USA. Stressors, such as high deer population density and low selenium levels, may have contributed to the development of clinical disease in this case and warrant further investigation.

Original languageEnglish (US)
Pages (from-to)201-206
Number of pages6
JournalJournal of Wildlife Diseases
Volume45
Issue number1
StatePublished - Jan 2009
Externally publishedYes

Fingerprint

Mycobacterium avium
paratuberculosis
Odocoileus virginianus
deer
subspecies
monitoring
diarrhea
infection
lymphadenitis
emaciation
hepatitis
histopathology
Mycobacterium avium subsp. paratuberculosis
ruminant
acids
acid
colitis
antibody detection
surveillance
selenium

Keywords

  • Diarrhea
  • Emaciation
  • Johne's disease
  • Mycobacterium avium subspecies paratuberculosis
  • Odocoileus virginianus
  • Paratuberculosis
  • White-tailed deer

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Ecology

Cite this

Johne's disease in a free-ranging white-tailed deer from virginia and subsequent surveillance for mycobacterium avium subspecies paratuberculosis. / Sleeman, Jonathan M.; Manning, Elizabeth J B; Rohm, John H.; Sims, Jerry P.; Sanchez, Susan; Gerhold, Richard W.; Keel, Michael K.

In: Journal of Wildlife Diseases, Vol. 45, No. 1, 01.2009, p. 201-206.

Research output: Contribution to journalArticle

Sleeman, Jonathan M. ; Manning, Elizabeth J B ; Rohm, John H. ; Sims, Jerry P. ; Sanchez, Susan ; Gerhold, Richard W. ; Keel, Michael K. / Johne's disease in a free-ranging white-tailed deer from virginia and subsequent surveillance for mycobacterium avium subspecies paratuberculosis. In: Journal of Wildlife Diseases. 2009 ; Vol. 45, No. 1. pp. 201-206.
@article{5ba8e4310fcd48b29787f1b30937b36f,
title = "Johne's disease in a free-ranging white-tailed deer from virginia and subsequent surveillance for mycobacterium avium subspecies paratuberculosis",
abstract = "Johne's disease (paratuberculosis) was diagnosed in a 2-yr-old, male, free-ranging white-tailed deer (Odocoileus virginianus) from Fauquier County, Virginia, USA, based on histopathology and culture for Mycobacterium avium subspecies paratuberculosis. Clinical and pathologic findings included emaciation; loss of body fat; chronic diarrhea; severe, chronic, diffuse granulomatous colitis with intrahistiocytic acid-fast bacilli; moderate, chronic granulomatous lymphadenitis with intrahistiocytic acid-fast bacilli; as well as moderate chronic, multifocal, lymphoplasmacytic hepatitis. These findings are consistent with previous reports of Johne's disease in cervids. Subsequent targeted surveillance of 10 emaciated deer with diarrhea, as well as sampling of 72 asymptomatic deer for M. avium subsp. paratuberculosis using culture of multiple tissue types, as well as serology using an. enzyme-linked immunosorbent assay (ELISA) optimized for cervid antibody detection, did not reveal any additional cases of infection in this geographic region. To date, this appears to be an isolated case of Johne's disease in a freeranging white-tailed deer, and infection with the causative agent for Johne's disease appears to be an infrequent occurrence in deer from this region. The origin of infection was most likely domestic ruminants. This is the first report of clinical Johne's disease in a freeranging white-tailed deer outside of the Florida Keys, USA. Stressors, such as high deer population density and low selenium levels, may have contributed to the development of clinical disease in this case and warrant further investigation.",
keywords = "Diarrhea, Emaciation, Johne's disease, Mycobacterium avium subspecies paratuberculosis, Odocoileus virginianus, Paratuberculosis, White-tailed deer",
author = "Sleeman, {Jonathan M.} and Manning, {Elizabeth J B} and Rohm, {John H.} and Sims, {Jerry P.} and Susan Sanchez and Gerhold, {Richard W.} and Keel, {Michael K}",
year = "2009",
month = "1",
language = "English (US)",
volume = "45",
pages = "201--206",
journal = "Journal of Wildlife Diseases",
issn = "0090-3558",
publisher = "Wildlife Disease Association, Inc.",
number = "1",

}

TY - JOUR

T1 - Johne's disease in a free-ranging white-tailed deer from virginia and subsequent surveillance for mycobacterium avium subspecies paratuberculosis

AU - Sleeman, Jonathan M.

AU - Manning, Elizabeth J B

AU - Rohm, John H.

AU - Sims, Jerry P.

AU - Sanchez, Susan

AU - Gerhold, Richard W.

AU - Keel, Michael K

PY - 2009/1

Y1 - 2009/1

N2 - Johne's disease (paratuberculosis) was diagnosed in a 2-yr-old, male, free-ranging white-tailed deer (Odocoileus virginianus) from Fauquier County, Virginia, USA, based on histopathology and culture for Mycobacterium avium subspecies paratuberculosis. Clinical and pathologic findings included emaciation; loss of body fat; chronic diarrhea; severe, chronic, diffuse granulomatous colitis with intrahistiocytic acid-fast bacilli; moderate, chronic granulomatous lymphadenitis with intrahistiocytic acid-fast bacilli; as well as moderate chronic, multifocal, lymphoplasmacytic hepatitis. These findings are consistent with previous reports of Johne's disease in cervids. Subsequent targeted surveillance of 10 emaciated deer with diarrhea, as well as sampling of 72 asymptomatic deer for M. avium subsp. paratuberculosis using culture of multiple tissue types, as well as serology using an. enzyme-linked immunosorbent assay (ELISA) optimized for cervid antibody detection, did not reveal any additional cases of infection in this geographic region. To date, this appears to be an isolated case of Johne's disease in a freeranging white-tailed deer, and infection with the causative agent for Johne's disease appears to be an infrequent occurrence in deer from this region. The origin of infection was most likely domestic ruminants. This is the first report of clinical Johne's disease in a freeranging white-tailed deer outside of the Florida Keys, USA. Stressors, such as high deer population density and low selenium levels, may have contributed to the development of clinical disease in this case and warrant further investigation.

AB - Johne's disease (paratuberculosis) was diagnosed in a 2-yr-old, male, free-ranging white-tailed deer (Odocoileus virginianus) from Fauquier County, Virginia, USA, based on histopathology and culture for Mycobacterium avium subspecies paratuberculosis. Clinical and pathologic findings included emaciation; loss of body fat; chronic diarrhea; severe, chronic, diffuse granulomatous colitis with intrahistiocytic acid-fast bacilli; moderate, chronic granulomatous lymphadenitis with intrahistiocytic acid-fast bacilli; as well as moderate chronic, multifocal, lymphoplasmacytic hepatitis. These findings are consistent with previous reports of Johne's disease in cervids. Subsequent targeted surveillance of 10 emaciated deer with diarrhea, as well as sampling of 72 asymptomatic deer for M. avium subsp. paratuberculosis using culture of multiple tissue types, as well as serology using an. enzyme-linked immunosorbent assay (ELISA) optimized for cervid antibody detection, did not reveal any additional cases of infection in this geographic region. To date, this appears to be an isolated case of Johne's disease in a freeranging white-tailed deer, and infection with the causative agent for Johne's disease appears to be an infrequent occurrence in deer from this region. The origin of infection was most likely domestic ruminants. This is the first report of clinical Johne's disease in a freeranging white-tailed deer outside of the Florida Keys, USA. Stressors, such as high deer population density and low selenium levels, may have contributed to the development of clinical disease in this case and warrant further investigation.

KW - Diarrhea

KW - Emaciation

KW - Johne's disease

KW - Mycobacterium avium subspecies paratuberculosis

KW - Odocoileus virginianus

KW - Paratuberculosis

KW - White-tailed deer

UR - http://www.scopus.com/inward/record.url?scp=65249171341&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=65249171341&partnerID=8YFLogxK

M3 - Article

C2 - 19204350

AN - SCOPUS:65249171341

VL - 45

SP - 201

EP - 206

JO - Journal of Wildlife Diseases

JF - Journal of Wildlife Diseases

SN - 0090-3558

IS - 1

ER -