Abstract
We describe a case of apparent mineralocorticoid excess (hypertension, hypokalemia, metabolic alkalosis and low plasma renin activity) secondary to itraconazole therapy. Inhibition of 11β-hydroxysteroid dehydrogenase 2 was demonstrated, and withholding itraconazole led to resolution of adverse effects that did not recur with voriconazole. This report adds to a growing body of evidence linking apparent mineralocorticoid excess with certain triazoles.
Original language | English (US) |
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Pages (from-to) | 337-339 |
Number of pages | 3 |
Journal | Mycoses |
Volume | 61 |
Issue number | 5 |
DOIs | |
State | Published - May 1 2018 |
Keywords
- hypertension
- itraconazole
- mineralocorticoid excess
- side-effects
ASJC Scopus subject areas
- Dermatology
- Infectious Diseases