Itraconazole induced hypertension and hypokalemia: Mechanistic evaluation

Wesley J. Hoffmann; Ian McHardy; George R. Thompson

doi:10.1111/myc.12749

Itraconazole induced hypertension and hypokalemia: Mechanistic evaluation

Wesley J. Hoffmann, Ian McHardy, George R. Thompson

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

We describe a case of apparent mineralocorticoid excess (hypertension, hypokalemia, metabolic alkalosis and low plasma renin activity) secondary to itraconazole therapy. Inhibition of 11β-hydroxysteroid dehydrogenase 2 was demonstrated, and withholding itraconazole led to resolution of adverse effects that did not recur with voriconazole. This report adds to a growing body of evidence linking apparent mineralocorticoid excess with certain triazoles.

Original language	English (US)
Pages (from-to)	337-339
Number of pages	3
Journal	Mycoses
Volume	61
Issue number	5
DOIs	https://doi.org/10.1111/myc.12749
State	Published - May 1 2018

Keywords

hypertension
itraconazole
mineralocorticoid excess
side-effects

ASJC Scopus subject areas

Dermatology
Infectious Diseases

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10.1111/myc.12749

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AB - We describe a case of apparent mineralocorticoid excess (hypertension, hypokalemia, metabolic alkalosis and low plasma renin activity) secondary to itraconazole therapy. Inhibition of 11β-hydroxysteroid dehydrogenase 2 was demonstrated, and withholding itraconazole led to resolution of adverse effects that did not recur with voriconazole. This report adds to a growing body of evidence linking apparent mineralocorticoid excess with certain triazoles.

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KW - side-effects

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Itraconazole induced hypertension and hypokalemia: Mechanistic evaluation

Abstract

Keywords

ASJC Scopus subject areas

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