Itraconazole induced hypertension and hypokalemia: Mechanistic evaluation

Wesley J. Hoffmann; Ian Howard Mchardy; George Richard Thompson

doi:10.1111/myc.12749

Itraconazole induced hypertension and hypokalemia: Mechanistic evaluation

Wesley J. Hoffmann, Ian Howard Mchardy, George Richard Thompson

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

We describe a case of apparent mineralocorticoid excess (hypertension, hypokalemia, metabolic alkalosis and low plasma renin activity) secondary to itraconazole therapy. Inhibition of 11β-hydroxysteroid dehydrogenase 2 was demonstrated, and withholding itraconazole led to resolution of adverse effects that did not recur with voriconazole. This report adds to a growing body of evidence linking apparent mineralocorticoid excess with certain triazoles.

Original language	English (US)
Pages (from-to)	337-339
Number of pages	3
Journal	Mycoses
Volume	61
Issue number	5
DOIs	https://doi.org/10.1111/myc.12749
State	Published - May 1 2018

Keywords

hypertension
itraconazole
mineralocorticoid excess
side-effects

ASJC Scopus subject areas

Dermatology
Infectious Diseases

Access to Document

10.1111/myc.12749

Fingerprint Dive into the research topics of 'Itraconazole induced hypertension and hypokalemia: Mechanistic evaluation'. Together they form a unique fingerprint.

Cite this

@article{9cfabba8035d49fc8439fc1c7253af7e,

title = "Itraconazole induced hypertension and hypokalemia: Mechanistic evaluation",

abstract = "We describe a case of apparent mineralocorticoid excess (hypertension, hypokalemia, metabolic alkalosis and low plasma renin activity) secondary to itraconazole therapy. Inhibition of 11β-hydroxysteroid dehydrogenase 2 was demonstrated, and withholding itraconazole led to resolution of adverse effects that did not recur with voriconazole. This report adds to a growing body of evidence linking apparent mineralocorticoid excess with certain triazoles.",

keywords = "hypertension, itraconazole, mineralocorticoid excess, side-effects",

author = "Hoffmann, {Wesley J.} and Mchardy, {Ian Howard} and Thompson, {George Richard}",

year = "2018",

month = may,

day = "1",

doi = "10.1111/myc.12749",

language = "English (US)",

volume = "61",

pages = "337--339",

journal = "Mycoses",

issn = "0933-7407",

publisher = "Wiley-Blackwell",

number = "5",

}

TY - JOUR

T1 - Itraconazole induced hypertension and hypokalemia

T2 - Mechanistic evaluation

AU - Hoffmann, Wesley J.

AU - Mchardy, Ian Howard

AU - Thompson, George Richard

PY - 2018/5/1

Y1 - 2018/5/1

N2 - We describe a case of apparent mineralocorticoid excess (hypertension, hypokalemia, metabolic alkalosis and low plasma renin activity) secondary to itraconazole therapy. Inhibition of 11β-hydroxysteroid dehydrogenase 2 was demonstrated, and withholding itraconazole led to resolution of adverse effects that did not recur with voriconazole. This report adds to a growing body of evidence linking apparent mineralocorticoid excess with certain triazoles.

AB - We describe a case of apparent mineralocorticoid excess (hypertension, hypokalemia, metabolic alkalosis and low plasma renin activity) secondary to itraconazole therapy. Inhibition of 11β-hydroxysteroid dehydrogenase 2 was demonstrated, and withholding itraconazole led to resolution of adverse effects that did not recur with voriconazole. This report adds to a growing body of evidence linking apparent mineralocorticoid excess with certain triazoles.

KW - hypertension

KW - itraconazole

KW - mineralocorticoid excess

KW - side-effects

UR - http://www.scopus.com/inward/record.url?scp=85045901916&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85045901916&partnerID=8YFLogxK

U2 - 10.1111/myc.12749

DO - 10.1111/myc.12749

M3 - Article

C2 - 29385285

AN - SCOPUS:85045901916

VL - 61

SP - 337

EP - 339

JO - Mycoses

JF - Mycoses

SN - 0933-7407

IS - 5

ER -