Issues related to development of new antiseizure treatments

Karen S. Wilcox, Tracy Dixon-Salazar, Graeme J. Sills, Elinor Ben-Menachem, H. Steve White, Roger J. Porter, Marc A. Dichter, Solomon L. Moshé, Jeffrey L. Noebels, Michael D. Privitera, Michael A Rogawski

Research output: Contribution to journalArticle

56 Scopus citations

Abstract

This report represents a summary of the discussions led by the antiseizure treatment working group of the International League Against Epilepsy (ILAE)/American Epilepsy Society (AES) Working Groups joint meeting in London (London Meeting). We review here what is currently known about the pharmacologic characteristics of current models of refractory seizures, both for adult and pediatric epilepsy. In addition, we address how the National Institute of Neurological Disorders and Stroke (NINDS)-funded Anticonvulsant Screening Program (ASP) is evolving to incorporate appropriate animal models in the search for molecules that might be sufficiently novel to warrant further pharmacologic development. We also briefly address what we believe is necessary, going forward, to achieve the goal of stopping seizures in all patients, with a call to arms for funding agencies, the pharmaceutical industry, and basic researchers. Wiley Periodicals, Inc.

Original languageEnglish (US)
Pages (from-to)24-34
Number of pages11
JournalEpilepsia
Volume54
Issue numberSUPPL.4
DOIs
StatePublished - Aug 2013

Keywords

  • Animal models of epilepsy
  • Antiseizure drug
  • Pharmacoresistant epilepsy

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology
  • Medicine(all)

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  • Cite this

    Wilcox, K. S., Dixon-Salazar, T., Sills, G. J., Ben-Menachem, E., White, H. S., Porter, R. J., Dichter, M. A., Moshé, S. L., Noebels, J. L., Privitera, M. D., & Rogawski, M. A. (2013). Issues related to development of new antiseizure treatments. Epilepsia, 54(SUPPL.4), 24-34. https://doi.org/10.1111/epi.12296