Issues in conducting a cancer risk assessment using epidemiologic data: Arsenic as a case study

Irva Hertz-Picciotto; D. A. Holtzman

Issues in conducting a cancer risk assessment using epidemiologic data: Arsenic as a case study

Research output: Contribution to journal › Article › peer-review

Abstract

Using human data to extrapolate cancer risks at ambient levels of airborne pollutants avoids the uncertainty due to interspecies differences, but introduces other uncertainties. The unusually extensive data relating lung cancer to occupational inhalation of arsenic provide examples of 3 uncertainties: the extrapolation from partial to full lifetime risks, from high to low doses, and between populations with differing smoking habits.

Original language	English (US)
Pages (from-to)	219-223
Number of pages	5
Journal	Experimental Pathology
Volume	37
Issue number	1-4
State	Published - 1989
Externally published	Yes

Keywords

airborne pollutants, cancer risk
arsenic
cancer risk, assessment
lung cancer
smoking habits

ASJC Scopus subject areas

Pathology and Forensic Medicine

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abstract = "Using human data to extrapolate cancer risks at ambient levels of airborne pollutants avoids the uncertainty due to interspecies differences, but introduces other uncertainties. The unusually extensive data relating lung cancer to occupational inhalation of arsenic provide examples of 3 uncertainties: the extrapolation from partial to full lifetime risks, from high to low doses, and between populations with differing smoking habits.",

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