Abstract
Background/Objectives: Sugar intake may be causally associated with chronic disease risk, either directly or by contributing to obesity. However, evidence from observational studies is mixed, in part due to the error and bias inherent in self-reported measures of sugar intake. Objective biomarkers may clarify the relationship between sugar intake and chronic disease risk. We have recently validated a biomarker of sugar intake in an Alaska Native (Yup'ik) study population that incorporates red blood cell carbon and nitrogen isotope ratios in a predictive model. This study tested associations of isotopic estimates of sugar intake with body mass index (BMI), waist circumference (WC) and a broad array of other physiological and biochemical measures of chronic disease risk in Yup'ik people. Subjects/Methods: In a cross-sectional sample of 1076 Yup'ik people, multiple linear regression was used to examine associations of sugar intake with BMI, WC and other chronic disease risk factors. Results: Isotopic estimates of sugar intake were not associated with BMI (P=0. 50) or WC (P=0. 85). They were positively associated with blood pressure, triglycerides (TG) and leptin, and are inversely associated with total-, high-density lipoprotein- and low-density lipoprotein-cholesterol and adiponectin. Conclusions: Isotopic estimates of sugar intake were not associated with obesity, but were adversely associated with other chronic disease risk factors in this Yup'ik study population. This first use of stable isotope markers of sugar intake may influence recommendations for sugar intake by Yup'ik people; however, longitudinal studies are required to understand associations with chronic disease incidence.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 91-96 |
| Number of pages | 6 |
| Journal | European Journal of Clinical Nutrition |
| Volume | 68 |
| Issue number | 1 |
| DOIs | |
| State | Published - 2014 |
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Keywords
- caloric sweeteners
- carbon
- chronic disease
- nitrogen
- risk factors
- stable isotope ratio
ASJC Scopus subject areas
- Medicine (miscellaneous)
- Nutrition and Dietetics
Cite this
Isotopic estimates of sugar intake are related to chronic disease risk factors but not obesity in an Alaska native (Yup'ik) study population. / Nash, S. H.; Kristal, A. R.; Bersamin, A.; Choy, K.; Hopkins, S. E.; Stanhope, Kimber; Havel, Peter J; Boyer, B. B.; O'Brien, D. M.
In: European Journal of Clinical Nutrition, Vol. 68, No. 1, 2014, p. 91-96.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Isotopic estimates of sugar intake are related to chronic disease risk factors but not obesity in an Alaska native (Yup'ik) study population
AU - Nash, S. H.
AU - Kristal, A. R.
AU - Bersamin, A.
AU - Choy, K.
AU - Hopkins, S. E.
AU - Stanhope, Kimber
AU - Havel, Peter J
AU - Boyer, B. B.
AU - O'Brien, D. M.
PY - 2014
Y1 - 2014
N2 - Background/Objectives: Sugar intake may be causally associated with chronic disease risk, either directly or by contributing to obesity. However, evidence from observational studies is mixed, in part due to the error and bias inherent in self-reported measures of sugar intake. Objective biomarkers may clarify the relationship between sugar intake and chronic disease risk. We have recently validated a biomarker of sugar intake in an Alaska Native (Yup'ik) study population that incorporates red blood cell carbon and nitrogen isotope ratios in a predictive model. This study tested associations of isotopic estimates of sugar intake with body mass index (BMI), waist circumference (WC) and a broad array of other physiological and biochemical measures of chronic disease risk in Yup'ik people. Subjects/Methods: In a cross-sectional sample of 1076 Yup'ik people, multiple linear regression was used to examine associations of sugar intake with BMI, WC and other chronic disease risk factors. Results: Isotopic estimates of sugar intake were not associated with BMI (P=0. 50) or WC (P=0. 85). They were positively associated with blood pressure, triglycerides (TG) and leptin, and are inversely associated with total-, high-density lipoprotein- and low-density lipoprotein-cholesterol and adiponectin. Conclusions: Isotopic estimates of sugar intake were not associated with obesity, but were adversely associated with other chronic disease risk factors in this Yup'ik study population. This first use of stable isotope markers of sugar intake may influence recommendations for sugar intake by Yup'ik people; however, longitudinal studies are required to understand associations with chronic disease incidence.
AB - Background/Objectives: Sugar intake may be causally associated with chronic disease risk, either directly or by contributing to obesity. However, evidence from observational studies is mixed, in part due to the error and bias inherent in self-reported measures of sugar intake. Objective biomarkers may clarify the relationship between sugar intake and chronic disease risk. We have recently validated a biomarker of sugar intake in an Alaska Native (Yup'ik) study population that incorporates red blood cell carbon and nitrogen isotope ratios in a predictive model. This study tested associations of isotopic estimates of sugar intake with body mass index (BMI), waist circumference (WC) and a broad array of other physiological and biochemical measures of chronic disease risk in Yup'ik people. Subjects/Methods: In a cross-sectional sample of 1076 Yup'ik people, multiple linear regression was used to examine associations of sugar intake with BMI, WC and other chronic disease risk factors. Results: Isotopic estimates of sugar intake were not associated with BMI (P=0. 50) or WC (P=0. 85). They were positively associated with blood pressure, triglycerides (TG) and leptin, and are inversely associated with total-, high-density lipoprotein- and low-density lipoprotein-cholesterol and adiponectin. Conclusions: Isotopic estimates of sugar intake were not associated with obesity, but were adversely associated with other chronic disease risk factors in this Yup'ik study population. This first use of stable isotope markers of sugar intake may influence recommendations for sugar intake by Yup'ik people; however, longitudinal studies are required to understand associations with chronic disease incidence.
KW - caloric sweeteners
KW - carbon
KW - chronic disease
KW - nitrogen
KW - risk factors
KW - stable isotope ratio
UR - http://www.scopus.com/inward/record.url?scp=84891875115&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84891875115&partnerID=8YFLogxK
U2 - 10.1038/ejcn.2013.230
DO - 10.1038/ejcn.2013.230
M3 - Article
C2 - 24219893
AN - SCOPUS:84891875115
VL - 68
SP - 91
EP - 96
JO - European Journal of Clinical Nutrition
JF - European Journal of Clinical Nutrition
SN - 0954-3007
IS - 1
ER -