Isoproterenol alters nonshivering thermogenesis in the Zucker obese rat (fafa)

Kathryn M. Milam; Judith S. Stern; Barbara A Horwitz

doi:10.1016/0091-3057(82)90427-0

Isoproterenol alters nonshivering thermogenesis in the Zucker obese rat (fafa)

Kathryn M. Milam, Judith S. Stern, Barbara A Horwitz

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

To test nonshivering thermogenic (NST) capacity of lean and obese Zucker rats, 4 doses of isoproterenol, ranging in concentration from 0.25 to 6.0 μg/min·kg^.75, were intravenously infused into 16 to 18 week old male rats, and oxygen consumption was continously monitored. Obese rats had a decreased NST response relative to lean littermates. This lowered thermogenic response of the obese rats cannot be attributed to a decreased mass of brown adipose tissue since both the cervical and interscapular depots from obese rats weighed significantly more than did those from lean rats.

Original language	English (US)
Pages (from-to)	627-630
Number of pages	4
Journal	Pharmacology, Biochemistry and Behavior
Volume	16
Issue number	4
DOIs	https://doi.org/10.1016/0091-3057(82)90427-0
State	Published - 1982

ASJC Scopus subject areas

Biochemistry
Behavioral Neuroscience
Pharmacology

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abstract = "To test nonshivering thermogenic (NST) capacity of lean and obese Zucker rats, 4 doses of isoproterenol, ranging in concentration from 0.25 to 6.0 μg/min·kg.75, were intravenously infused into 16 to 18 week old male rats, and oxygen consumption was continously monitored. Obese rats had a decreased NST response relative to lean littermates. This lowered thermogenic response of the obese rats cannot be attributed to a decreased mass of brown adipose tissue since both the cervical and interscapular depots from obese rats weighed significantly more than did those from lean rats.",

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AU - Stern, Judith S.

AU - Horwitz, Barbara A

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AB - To test nonshivering thermogenic (NST) capacity of lean and obese Zucker rats, 4 doses of isoproterenol, ranging in concentration from 0.25 to 6.0 μg/min·kg.75, were intravenously infused into 16 to 18 week old male rats, and oxygen consumption was continously monitored. Obese rats had a decreased NST response relative to lean littermates. This lowered thermogenic response of the obese rats cannot be attributed to a decreased mass of brown adipose tissue since both the cervical and interscapular depots from obese rats weighed significantly more than did those from lean rats.

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Isoproterenol alters nonshivering thermogenesis in the Zucker obese rat (fafa)

Abstract

ASJC Scopus subject areas

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