Abstract
To test nonshivering thermogenic (NST) capacity of lean and obese Zucker rats, 4 doses of isoproterenol, ranging in concentration from 0.25 to 6.0 μg/min·kg.75, were intravenously infused into 16 to 18 week old male rats, and oxygen consumption was continously monitored. Obese rats had a decreased NST response relative to lean littermates. This lowered thermogenic response of the obese rats cannot be attributed to a decreased mass of brown adipose tissue since both the cervical and interscapular depots from obese rats weighed significantly more than did those from lean rats.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 627-630 |
| Number of pages | 4 |
| Journal | Pharmacology, Biochemistry and Behavior |
| Volume | 16 |
| Issue number | 4 |
| DOIs | |
| State | Published - 1982 |
ASJC Scopus subject areas
- Biochemistry
- Behavioral Neuroscience
- Pharmacology
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Cite this
Milam, K. M., Stern, J. S., & Horwitz, B. A. (1982). Isoproterenol alters nonshivering thermogenesis in the Zucker obese rat (fafa). Pharmacology, Biochemistry and Behavior, 16(4), 627-630. https://doi.org/10.1016/0091-3057(82)90427-0