Isoproterenol alters nonshivering thermogenesis in the Zucker obese rat (fafa)

Kathryn M. Milam, Judith S. Stern, Barbara A Horwitz

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

To test nonshivering thermogenic (NST) capacity of lean and obese Zucker rats, 4 doses of isoproterenol, ranging in concentration from 0.25 to 6.0 μg/min·kg.75, were intravenously infused into 16 to 18 week old male rats, and oxygen consumption was continously monitored. Obese rats had a decreased NST response relative to lean littermates. This lowered thermogenic response of the obese rats cannot be attributed to a decreased mass of brown adipose tissue since both the cervical and interscapular depots from obese rats weighed significantly more than did those from lean rats.

Original languageEnglish (US)
Pages (from-to)627-630
Number of pages4
JournalPharmacology, Biochemistry and Behavior
Volume16
Issue number4
DOIs
StatePublished - 1982

ASJC Scopus subject areas

  • Biochemistry
  • Behavioral Neuroscience
  • Pharmacology

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