Abstract
To test nonshivering thermogenic (NST) capacity of lean and obese Zucker rats, 4 doses of isoproterenol, ranging in concentration from 0.25 to 6.0 μg/min·kg.75, were intravenously infused into 16 to 18 week old male rats, and oxygen consumption was continously monitored. Obese rats had a decreased NST response relative to lean littermates. This lowered thermogenic response of the obese rats cannot be attributed to a decreased mass of brown adipose tissue since both the cervical and interscapular depots from obese rats weighed significantly more than did those from lean rats.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 627-630 |
| Number of pages | 4 |
| Journal | Pharmacology, Biochemistry and Behavior |
| Volume | 16 |
| Issue number | 4 |
| DOIs | |
| State | Published - 1982 |
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ASJC Scopus subject areas
- Biochemistry
- Behavioral Neuroscience
- Pharmacology
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Isoproterenol alters nonshivering thermogenesis in the Zucker obese rat (fafa). / Milam, Kathryn M.; Stern, Judith S.; Horwitz, Barbara A.
In: Pharmacology, Biochemistry and Behavior, Vol. 16, No. 4, 1982, p. 627-630.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Isoproterenol alters nonshivering thermogenesis in the Zucker obese rat (fafa)
AU - Milam, Kathryn M.
AU - Stern, Judith S.
AU - Horwitz, Barbara A
PY - 1982
Y1 - 1982
N2 - To test nonshivering thermogenic (NST) capacity of lean and obese Zucker rats, 4 doses of isoproterenol, ranging in concentration from 0.25 to 6.0 μg/min·kg.75, were intravenously infused into 16 to 18 week old male rats, and oxygen consumption was continously monitored. Obese rats had a decreased NST response relative to lean littermates. This lowered thermogenic response of the obese rats cannot be attributed to a decreased mass of brown adipose tissue since both the cervical and interscapular depots from obese rats weighed significantly more than did those from lean rats.
AB - To test nonshivering thermogenic (NST) capacity of lean and obese Zucker rats, 4 doses of isoproterenol, ranging in concentration from 0.25 to 6.0 μg/min·kg.75, were intravenously infused into 16 to 18 week old male rats, and oxygen consumption was continously monitored. Obese rats had a decreased NST response relative to lean littermates. This lowered thermogenic response of the obese rats cannot be attributed to a decreased mass of brown adipose tissue since both the cervical and interscapular depots from obese rats weighed significantly more than did those from lean rats.
UR - http://www.scopus.com/inward/record.url?scp=0020024760&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0020024760&partnerID=8YFLogxK
U2 - 10.1016/0091-3057(82)90427-0
DO - 10.1016/0091-3057(82)90427-0
M3 - Article
C2 - 7071094
AN - SCOPUS:0020024760
VL - 16
SP - 627
EP - 630
JO - Pharmacology Biochemistry and Behavior
JF - Pharmacology Biochemistry and Behavior
SN - 0091-3057
IS - 4
ER -