Isoniazid Overdose: Pharmacokinetics and Effects of Oral Charcoal in Treatment

A. D. Siefkin, Timothy E Albertson, M. G. Corbett

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

The pharmacokinetics of isoniazid following overdose in two patients is described. One patient was treated with haemodialysis for seizures and persistent coma without obvious immediate clinical improvement. In addition, three volunteer subjects were given isoniazid orally on two separate occasions. Isoniazid elimination pharmacokinetics were determined with and without concominant charcoal. Oral activated charcoal totally prevented the absorption of isoniazid. Current recommendations for treatment of isoniazid overdoses include intravenous pyridoxine (one gram I.V. pyridoxine for each gram of ingested isoniazid), intravenous diazepam or phenobarbital for continued seizures, and gastric decontamination with lavage and activated charcoal (1 g/kg). Extraordinary measures such as early haemodialysis and haemoperfusion should be reserved for those patients with persistent coma or refractory seizures.

Original languageEnglish (US)
Pages (from-to)497-501
Number of pages5
JournalHuman and Experimental Toxicology
Volume6
Issue number6
DOIs
StatePublished - 1987

ASJC Scopus subject areas

  • Toxicology
  • Health, Toxicology and Mutagenesis

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