Isoniazid overdose: pharmacokinetics and effects of oral charcoal in treatment

A. D. Siefkin, T. E. Albertson, M. G. Corbett

Research output: Contribution to journalArticle

Abstract

The pharmacokinetics of isoniazid following overdose in two patients is described. One patient was treated with haemodialysis for seizures and persistent coma without obvious immediate clinical improvement. In addition, three volunteer subjects were given isoniazid orally on two separate occasions. Isoniazid elimination pharmacokinetics were determined with and without concominant charcoal. Oral activated charcoal totally prevented the absorption of isoniazid. Current recommendations for treatment of isoniazid overdoses include intravenous pyridoxine (one gram IV pyridoxine for each gram of ingested isoniazid, intravenous diazepan or phenobarbital for continued seizures, and gastric decontamination with lavage and activated charcoal (1 g/kg). Extraordinary measures such as early haemodialysis and haemoperfusion should be reserved for those patiens with persistant coma or refractory seizures.

Original languageEnglish (US)
Pages (from-to)497-501
Number of pages5
JournalHuman Toxicology
Volume6
Issue number6
StatePublished - 1987

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Pharmacokinetics
Charcoal
Isoniazid
Pyridoxine
Seizures
Coma
Renal Dialysis
Therapeutics
Hemoperfusion
Decontamination
Therapeutic Irrigation
Phenobarbital
Refractory materials
Volunteers
Stomach

ASJC Scopus subject areas

  • Toxicology

Cite this

Isoniazid overdose : pharmacokinetics and effects of oral charcoal in treatment. / Siefkin, A. D.; Albertson, T. E.; Corbett, M. G.

In: Human Toxicology, Vol. 6, No. 6, 1987, p. 497-501.

Research output: Contribution to journalArticle

Siefkin, A. D. ; Albertson, T. E. ; Corbett, M. G. / Isoniazid overdose : pharmacokinetics and effects of oral charcoal in treatment. In: Human Toxicology. 1987 ; Vol. 6, No. 6. pp. 497-501.
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