Abstract
An emerging theme in neurodegenerative diseases is the aggregation of proteins as inclusions in neural cells. Their presence is a useful tool in the differential diagnosis of the particular illness, although in no instance is the specific role of the inclusions in disease pathogenesis understood at present. However, apart from their role in the disease mechanism, the inclusions themselves may contain important molecular clues as to the mechanism(s) behind the specific inclusion-associated disease. Thus, isolation and analysis of the composition of the inclusions is likely to yield biochemical evidence of the cellular pathways that are involved in the disease process.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 181-190 |
| Number of pages | 10 |
| Journal | Methods in molecular biology (Clifton, N.J.) |
| Volume | 463 |
| DOIs | |
| State | Published - Jan 1 2008 |
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ASJC Scopus subject areas
- Molecular Biology
- Genetics
Cite this
Isolation of pathology-associated intranuclear inclusions. / Iwahashi, Christine; Hagerman, Paul J.
In: Methods in molecular biology (Clifton, N.J.), Vol. 463, 01.01.2008, p. 181-190.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Isolation of pathology-associated intranuclear inclusions
AU - Iwahashi, Christine
AU - Hagerman, Paul J
PY - 2008/1/1
Y1 - 2008/1/1
N2 - An emerging theme in neurodegenerative diseases is the aggregation of proteins as inclusions in neural cells. Their presence is a useful tool in the differential diagnosis of the particular illness, although in no instance is the specific role of the inclusions in disease pathogenesis understood at present. However, apart from their role in the disease mechanism, the inclusions themselves may contain important molecular clues as to the mechanism(s) behind the specific inclusion-associated disease. Thus, isolation and analysis of the composition of the inclusions is likely to yield biochemical evidence of the cellular pathways that are involved in the disease process.
AB - An emerging theme in neurodegenerative diseases is the aggregation of proteins as inclusions in neural cells. Their presence is a useful tool in the differential diagnosis of the particular illness, although in no instance is the specific role of the inclusions in disease pathogenesis understood at present. However, apart from their role in the disease mechanism, the inclusions themselves may contain important molecular clues as to the mechanism(s) behind the specific inclusion-associated disease. Thus, isolation and analysis of the composition of the inclusions is likely to yield biochemical evidence of the cellular pathways that are involved in the disease process.
UR - http://www.scopus.com/inward/record.url?scp=85052549673&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85052549673&partnerID=8YFLogxK
U2 - 10.1007/978-1-59745-406-3_13
DO - 10.1007/978-1-59745-406-3_13
M3 - Article
C2 - 18951169
AN - SCOPUS:85052549673
VL - 463
SP - 181
EP - 190
JO - Methods in molecular biology (Clifton, N.J.)
JF - Methods in molecular biology (Clifton, N.J.)
SN - 1064-3745
ER -