Isolation of disease resistance genes from crop plants

Richard W Michelmore

Research output: Contribution to journalArticlepeer-review

19 Scopus citations


The recent cloning of several resistance genes from diverse plant species, in combination with various technical advances, has provided new opportunities for accessing the great diversity of disease resistance genes in crop plants. Many resistance genes probably belong to clusters of large multigene families encoding receptor-like proteins that have evolved to have different specificities. The isolation of genes from crop species is being facilitated by continuing technical improvements to methods for the saturation of markers within genomic regions containing resistance genes, for the cloning and characterization of large genomic fragments, and for efficient complementation. The primary limitation to cloning resistance genes with known specificities will be the genetic definition of the targeted gene.

Original languageEnglish (US)
Pages (from-to)145-152
Number of pages8
JournalCurrent Opinion in Biotechnology
Issue number2
StatePublished - 1995

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Biomedical Engineering


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