Isolation of a T-lymphotropic virus from domestic cats with an immunodeficiency-like syndrome

Niels C Pedersen, E. W. Ho, M. L. Brown, J. K. Yamamoto

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Abstract

A highly T-lymphotropic virus was isolated from cats in a cattery in which all the animals were seronegative for feline leukemia virus. A number of cats in one pen had died and several had an immunodeficiency-like syndrome. Only 1 of 18 normal cats in the cattery showed serologic evidence of infection with this new virus, whereas 10 of 25 cats with signs of ill health were seropositive for the virus. Tentatively designated feline T-lymphotropic lentivirus, this new feline retrovirus appears to be antigenically distinct from human immunodeficiency virus. There is no evidence for cat-to-human transmission of the agent. Kittens experimentally infected by way of blood or plasma from naturally infected animals developed generalized lymphadenopathy several weeks later, became transiently febrile and leukopenic, and continued to show a generalized lymphadenopathy 5 months after infection.

Original languageEnglish (US)
Pages (from-to)790-793
Number of pages4
JournalScience
Volume235
Issue number4790
StatePublished - 1987

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Cats
Viruses
Feline Leukemia Virus
Feline Immunodeficiency Virus
Felidae
Retroviridae
Infection
Fever
HIV
Health
Lymphadenopathy

ASJC Scopus subject areas

  • General

Cite this

Pedersen, N. C., Ho, E. W., Brown, M. L., & Yamamoto, J. K. (1987). Isolation of a T-lymphotropic virus from domestic cats with an immunodeficiency-like syndrome. Science, 235(4790), 790-793.

Isolation of a T-lymphotropic virus from domestic cats with an immunodeficiency-like syndrome. / Pedersen, Niels C; Ho, E. W.; Brown, M. L.; Yamamoto, J. K.

In: Science, Vol. 235, No. 4790, 1987, p. 790-793.

Research output: Contribution to journalArticle

Pedersen, NC, Ho, EW, Brown, ML & Yamamoto, JK 1987, 'Isolation of a T-lymphotropic virus from domestic cats with an immunodeficiency-like syndrome', Science, vol. 235, no. 4790, pp. 790-793.
Pedersen, Niels C ; Ho, E. W. ; Brown, M. L. ; Yamamoto, J. K. / Isolation of a T-lymphotropic virus from domestic cats with an immunodeficiency-like syndrome. In: Science. 1987 ; Vol. 235, No. 4790. pp. 790-793.
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