Isolation of a novel adenovirus from California sea lions Zalophus californianus

Tracey Goldstein, K. M. Colegrove, M. Hanson, F. M D Gulland

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Viral hepatitis associated with adenoviral infection has been reported in California sea lions Zalophus californianus admitted to rehabilitation centers along the California coast since the 1970s. Canine adenovirus 1 (CAdV-1) causes viral hepatitis in dogs and infects a number of wildlife species. Attempts to isolate the virus from previous sea lion hepatitis cases were unsuccessful, but as the hepatitis had morphologic features resembling canine infectious hepatitis, and since the virus has a wide host range, it was thought that perhaps the etiologic agent was CAdV-1. Here, we identify a novel adenovirus in 2 stranded California sea lions and associate the infection with viral hepatitis and endothelial cell infection. Phylogenetic analysis confirmed the classification of the sea lion adenovirus in the Mastadenovirus genus with the most similarity to tree shrew adenovirus 1 (TSAdV-1, 77%). However, as the sea lion adenovirus appeared to be equally distant from the other Mastadenovirus species based on phylogenetic analysis, results indicate that it represents an independent lineage and species. Although sequences from this novel virus, otarine adenovirus 1 (OtAdV-1), show some similarity to CAdV-1 and 2, it is clearly distinct and likely the cause of the viral hepatitis in the stranded California sea lions.

Original languageEnglish (US)
Pages (from-to)243-248
Number of pages6
JournalDiseases of Aquatic Organisms
Volume94
Issue number3
DOIs
StatePublished - May 9 2011

Fingerprint

Canine adenovirus A
viral hepatitis
hepatitis
pinniped
Adenoviridae
Tree shrew adenovirus A
Mastadenovirus
Otariidae
viruses
infectious canine hepatitis
infection
virus
phylogeny
host range
endothelial cells
wildlife
phylogenetics
coasts
Zalophus californianus
dogs

Keywords

  • Adenovirus
  • California sea lion
  • Corneal edema
  • Viral hepatitis
  • Zalophus californianus

ASJC Scopus subject areas

  • Aquatic Science
  • Ecology, Evolution, Behavior and Systematics

Cite this

Isolation of a novel adenovirus from California sea lions Zalophus californianus. / Goldstein, Tracey; Colegrove, K. M.; Hanson, M.; Gulland, F. M D.

In: Diseases of Aquatic Organisms, Vol. 94, No. 3, 09.05.2011, p. 243-248.

Research output: Contribution to journalArticle

Goldstein, Tracey ; Colegrove, K. M. ; Hanson, M. ; Gulland, F. M D. / Isolation of a novel adenovirus from California sea lions Zalophus californianus. In: Diseases of Aquatic Organisms. 2011 ; Vol. 94, No. 3. pp. 243-248.
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