Isolation of a new serotype of simian acquired immune deficiency syndrome type D retrovirus from Celebes black macaques (Macaca nigra) with immune deficiency and retroperitoneal fibromatosis

P. A. Marx, M. L. Bryant, K. G. Osborn, D. H. Maul, N. W. Lerche, Linda J Lowenstine, J. D. Kluge, C. P. Zaiss, R. V. Henrickson, S. M. Shiigi

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Abstract

A new serotype of simian acquired immune deficiency syndrome (SAIDS) retrovirus (type 2) belonging to the D genus of retroviruses is associated with a SAIDS occurring spontaneously in a colony of Celebes macaques (Macaca nigra) and rhesus macaques (Macaca mulatta) at the Oregon Regional Primate Research Center. This syndrome resembles SAIDS in M. mulatta at the California Primate Research Center, which is associated with a similar type D retrovirus (type 1). However, at the Oregon Center, SAIDS is distinguished by the occurrence of retroperitoneal fibromatosis in some of the affected monkeys. Type 2 virus was isolated from seven of seven macaques with SAIDS, retroperitoneal fibromatosis, or both and from one of six healthy macaques. The new strain is closely related to SAIDS retrovirus type 1 and Mason-Pfizer monkey virus but can be distinguished by competitive radioimmunoassay for minor core (p10) antigen and by genomic restriction endonuclease cleavage patterns. Neutralization tests indicate that type 1 and type 2 SAIDS retroviruses are distinct serotypes. Therefore, separate vaccines may be necessary to control these infections in colonies of captive macaques.

Original languageEnglish (US)
Pages (from-to)571-578
Number of pages8
JournalJournal of Virology
Volume56
Issue number2
StatePublished - 1985

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Simian Acquired Immunodeficiency Syndrome
Betaretrovirus
acquired immunodeficiency syndrome
Fibroma
Indonesia
immunosuppression
Macaca
Retroviridae
serotypes
Macaca mulatta
Primates
Mason-Pfizer monkey virus
Neutralization Tests
DNA Restriction Enzymes
restriction endonucleases
neutralization tests
Infection Control
Serogroup
radioimmunoassays
Research

ASJC Scopus subject areas

  • Immunology

Cite this

Isolation of a new serotype of simian acquired immune deficiency syndrome type D retrovirus from Celebes black macaques (Macaca nigra) with immune deficiency and retroperitoneal fibromatosis. / Marx, P. A.; Bryant, M. L.; Osborn, K. G.; Maul, D. H.; Lerche, N. W.; Lowenstine, Linda J; Kluge, J. D.; Zaiss, C. P.; Henrickson, R. V.; Shiigi, S. M.

In: Journal of Virology, Vol. 56, No. 2, 1985, p. 571-578.

Research output: Contribution to journalArticle

Marx, P. A. ; Bryant, M. L. ; Osborn, K. G. ; Maul, D. H. ; Lerche, N. W. ; Lowenstine, Linda J ; Kluge, J. D. ; Zaiss, C. P. ; Henrickson, R. V. ; Shiigi, S. M. / Isolation of a new serotype of simian acquired immune deficiency syndrome type D retrovirus from Celebes black macaques (Macaca nigra) with immune deficiency and retroperitoneal fibromatosis. In: Journal of Virology. 1985 ; Vol. 56, No. 2. pp. 571-578.
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abstract = "A new serotype of simian acquired immune deficiency syndrome (SAIDS) retrovirus (type 2) belonging to the D genus of retroviruses is associated with a SAIDS occurring spontaneously in a colony of Celebes macaques (Macaca nigra) and rhesus macaques (Macaca mulatta) at the Oregon Regional Primate Research Center. This syndrome resembles SAIDS in M. mulatta at the California Primate Research Center, which is associated with a similar type D retrovirus (type 1). However, at the Oregon Center, SAIDS is distinguished by the occurrence of retroperitoneal fibromatosis in some of the affected monkeys. Type 2 virus was isolated from seven of seven macaques with SAIDS, retroperitoneal fibromatosis, or both and from one of six healthy macaques. The new strain is closely related to SAIDS retrovirus type 1 and Mason-Pfizer monkey virus but can be distinguished by competitive radioimmunoassay for minor core (p10) antigen and by genomic restriction endonuclease cleavage patterns. Neutralization tests indicate that type 1 and type 2 SAIDS retroviruses are distinct serotypes. Therefore, separate vaccines may be necessary to control these infections in colonies of captive macaques.",
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