TY - JOUR
T1 - Isolation of a low molecular weight zinc binding ligand from human milk
AU - Lönnerdal, Bo
AU - Stanislowski, Anna G.
AU - Hurley, Lucille S.
PY - 1980
Y1 - 1980
N2 - A low molecular weight zinc binding compound from human milk has been purified by ultrafiltration, gel filtration, and ion-exchange chromatography. Evidence is provided that this compound is citrate. A higher amount of citrate-bound zinc was found in human milk than in cow's milk. It is suggested that the therapeutic value of human milk for patients with the genetic disorder of zinc metabolism acrodermatitis enteropathica (AE) derives from a greater content of bioavailable zinc citrate in human than in cow's milk.
AB - A low molecular weight zinc binding compound from human milk has been purified by ultrafiltration, gel filtration, and ion-exchange chromatography. Evidence is provided that this compound is citrate. A higher amount of citrate-bound zinc was found in human milk than in cow's milk. It is suggested that the therapeutic value of human milk for patients with the genetic disorder of zinc metabolism acrodermatitis enteropathica (AE) derives from a greater content of bioavailable zinc citrate in human than in cow's milk.
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U2 - 10.1016/S0162-0134(00)80044-6
DO - 10.1016/S0162-0134(00)80044-6
M3 - Article
C2 - 7189547
AN - SCOPUS:0018871097
VL - 12
SP - 71
EP - 78
JO - Journal of Inorganic Biochemistry
JF - Journal of Inorganic Biochemistry
SN - 0162-0134
IS - 1
ER -