Isolation of a low molecular weight zinc binding ligand from human milk

Bo Lönnerdal; Anna G. Stanislowski; Lucille S. Hurley

doi:10.1016/S0162-0134(00)80044-6

Isolation of a low molecular weight zinc binding ligand from human milk

Bo Lönnerdal, Anna G. Stanislowski, Lucille S. Hurley

Endocrinology, Diabetes, and Metabolism

Research output: Contribution to journal › Article › peer-review

129 Scopus citations

Abstract

A low molecular weight zinc binding compound from human milk has been purified by ultrafiltration, gel filtration, and ion-exchange chromatography. Evidence is provided that this compound is citrate. A higher amount of citrate-bound zinc was found in human milk than in cow's milk. It is suggested that the therapeutic value of human milk for patients with the genetic disorder of zinc metabolism acrodermatitis enteropathica (AE) derives from a greater content of bioavailable zinc citrate in human than in cow's milk.

Original language	English (US)
Pages (from-to)	71-78
Number of pages	8
Journal	Journal of Inorganic Biochemistry
Volume	12
Issue number	1
DOIs	https://doi.org/10.1016/S0162-0134(00)80044-6
State	Published - 1980

ASJC Scopus subject areas

Biochemistry
Inorganic Chemistry

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