Isolation of a low molecular weight zinc binding ligand from human milk

Bo Lönnerdal, Anna G. Stanislowski, Lucille S. Hurley

Research output: Contribution to journalArticlepeer-review

129 Scopus citations

Abstract

A low molecular weight zinc binding compound from human milk has been purified by ultrafiltration, gel filtration, and ion-exchange chromatography. Evidence is provided that this compound is citrate. A higher amount of citrate-bound zinc was found in human milk than in cow's milk. It is suggested that the therapeutic value of human milk for patients with the genetic disorder of zinc metabolism acrodermatitis enteropathica (AE) derives from a greater content of bioavailable zinc citrate in human than in cow's milk.

Original languageEnglish (US)
Pages (from-to)71-78
Number of pages8
JournalJournal of Inorganic Biochemistry
Volume12
Issue number1
DOIs
StatePublished - 1980

ASJC Scopus subject areas

  • Biochemistry
  • Inorganic Chemistry

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