Abstract
The bursa of Fabricius (BF) is the central humoral immune organ unique to birds which plays important roles in B lymphocyte differentiation. Here, a new bursal peptide (BP11) with the amino acid sequence DVAGKLPDNRT was identified and characterized from BF. It was proved that BP11 promoted CFU pre-B formation, and regulated B cell differentiation, including increase the percentage of immature and mature B cells in BM cells co-cultured with IL-7. BP11 also exerted immunomodulatory function on antigen-specific immune responses in BALB/c mice immunized with inactivated influence virus (AIV, H9N2 subtype) vaccine, including enhancing AIV-specific antibody and cytokine production. Furthermore, it was noteworthy that BP11 stimulated antibody productions and potentiates the Th1 and Th2-type immune responses in dose-dependent manner in chicken. These results suggested that BP11 might be highly relevant for the development of avian immune system.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 107-113 |
| Number of pages | 7 |
| Journal | Peptides |
| Volume | 35 |
| Issue number | 1 |
| DOIs | |
| State | Published - May 1 2012 |
| Externally published | Yes |
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Keywords
- B cell development
- Bursal peptide (BP11)
- Immunization experiment
- Immunomodulatory function
ASJC Scopus subject areas
- Biochemistry
- Physiology
- Endocrinology
- Cellular and Molecular Neuroscience
Cite this
Isolation, modulatory functions on murine B cell development and antigen-specific immune responses of BP11, a novel peptide from the chicken bursa of Fabricius. / Liu, Xiao Dong; Feng, Xiuli; Zhou, Bin; Cao, Rui Bing; Li, Xin Feng; Ma, Zhi Yong; Chen, Pu Yan.
In: Peptides, Vol. 35, No. 1, 01.05.2012, p. 107-113.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Isolation, modulatory functions on murine B cell development and antigen-specific immune responses of BP11, a novel peptide from the chicken bursa of Fabricius
AU - Liu, Xiao Dong
AU - Feng, Xiuli
AU - Zhou, Bin
AU - Cao, Rui Bing
AU - Li, Xin Feng
AU - Ma, Zhi Yong
AU - Chen, Pu Yan
PY - 2012/5/1
Y1 - 2012/5/1
N2 - The bursa of Fabricius (BF) is the central humoral immune organ unique to birds which plays important roles in B lymphocyte differentiation. Here, a new bursal peptide (BP11) with the amino acid sequence DVAGKLPDNRT was identified and characterized from BF. It was proved that BP11 promoted CFU pre-B formation, and regulated B cell differentiation, including increase the percentage of immature and mature B cells in BM cells co-cultured with IL-7. BP11 also exerted immunomodulatory function on antigen-specific immune responses in BALB/c mice immunized with inactivated influence virus (AIV, H9N2 subtype) vaccine, including enhancing AIV-specific antibody and cytokine production. Furthermore, it was noteworthy that BP11 stimulated antibody productions and potentiates the Th1 and Th2-type immune responses in dose-dependent manner in chicken. These results suggested that BP11 might be highly relevant for the development of avian immune system.
AB - The bursa of Fabricius (BF) is the central humoral immune organ unique to birds which plays important roles in B lymphocyte differentiation. Here, a new bursal peptide (BP11) with the amino acid sequence DVAGKLPDNRT was identified and characterized from BF. It was proved that BP11 promoted CFU pre-B formation, and regulated B cell differentiation, including increase the percentage of immature and mature B cells in BM cells co-cultured with IL-7. BP11 also exerted immunomodulatory function on antigen-specific immune responses in BALB/c mice immunized with inactivated influence virus (AIV, H9N2 subtype) vaccine, including enhancing AIV-specific antibody and cytokine production. Furthermore, it was noteworthy that BP11 stimulated antibody productions and potentiates the Th1 and Th2-type immune responses in dose-dependent manner in chicken. These results suggested that BP11 might be highly relevant for the development of avian immune system.
KW - B cell development
KW - Bursal peptide (BP11)
KW - Immunization experiment
KW - Immunomodulatory function
UR - http://www.scopus.com/inward/record.url?scp=84862814332&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84862814332&partnerID=8YFLogxK
U2 - 10.1016/j.peptides.2012.03.003
DO - 10.1016/j.peptides.2012.03.003
M3 - Article
C2 - 22429726
AN - SCOPUS:84862814332
VL - 35
SP - 107
EP - 113
JO - Peptides
JF - Peptides
SN - 0196-9781
IS - 1
ER -