Isolation, modulatory functions on murine B cell development and antigen-specific immune responses of BP11, a novel peptide from the chicken bursa of Fabricius

Xiao Dong Liu, Xiuli Feng, Bin Zhou, Rui Bing Cao, Xin Feng Li, Zhi Yong Ma, Pu Yan Chen

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

The bursa of Fabricius (BF) is the central humoral immune organ unique to birds which plays important roles in B lymphocyte differentiation. Here, a new bursal peptide (BP11) with the amino acid sequence DVAGKLPDNRT was identified and characterized from BF. It was proved that BP11 promoted CFU pre-B formation, and regulated B cell differentiation, including increase the percentage of immature and mature B cells in BM cells co-cultured with IL-7. BP11 also exerted immunomodulatory function on antigen-specific immune responses in BALB/c mice immunized with inactivated influence virus (AIV, H9N2 subtype) vaccine, including enhancing AIV-specific antibody and cytokine production. Furthermore, it was noteworthy that BP11 stimulated antibody productions and potentiates the Th1 and Th2-type immune responses in dose-dependent manner in chicken. These results suggested that BP11 might be highly relevant for the development of avian immune system.

Original languageEnglish (US)
Pages (from-to)107-113
Number of pages7
JournalPeptides
Volume35
Issue number1
DOIs
StatePublished - May 1 2012
Externally publishedYes

Keywords

  • B cell development
  • Bursal peptide (BP11)
  • Immunization experiment
  • Immunomodulatory function

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Endocrinology
  • Cellular and Molecular Neuroscience

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