Isolation, antiproliferation on tumor cell and immunomodulatory activity of BSP-I, a novel bursal peptide from chicken humoral immune system

Xiuli Feng, Taoqing Liu, Fangquan Wang, Ruibing Cao, Bin Zhou, Yu Zhang, Xiang Mao, Puyan Chen, Hui Zhang

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

The bursa of Fabricius (BF) is acknowledged as central humoral immune organ unique to birds. Our purpose was to identify the potential function of a novel bursal-derived bioactive peptide. A bursal septpeptide (BSP-I), EPASGMM, first isolated from BF, reduced MCF and Hela tumor cells proliferation, and enhanced antitumor factor p53 luciferase activity and protein expression. Further, we found the significantly immune inducing function of BSP-I on antigen-specific immune response in BALB/c mice intraperitoneally immunized with inactivated avian influence virus (AIV, H9N2 subtype) vaccine, including of enhancing the antibody (IgG, the isotypes IgG1 and IgG2a) production, and stimulating cytokines IL-4 and IFN-γ level, and inducing T cell immunophenotyping and lymphocyte proliferation. These results suggested that as the bioactive peptide from avian humoral immune system, various biological function of BSP-I may have far-reaching implication on immune system significance, which might provide novel insight on linking between humoral immune system and development of effective immunotherapeutic strategies for treating human cancers diseases.

Original languageEnglish (US)
Pages (from-to)1103-1109
Number of pages7
JournalPeptides
Volume32
Issue number6
DOIs
StatePublished - Jun 1 2011
Externally publishedYes

Keywords

  • Antiproliferation on tumor cell
  • Antitumor factor p53
  • Bursal septpeptide (BSP-I)
  • Cellular-mediated immunity
  • Humoral immune response

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Endocrinology
  • Cellular and Molecular Neuroscience

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