Isolation and characterization of lon mutants in Salmonella typhimurium

D. Downs, L. Waxman, A. L. Goldberg, J. Roth

Research output: Contribution to journalArticlepeer-review

18 Scopus citations


In this paper we report the isolation and characterization of lon mutants in Salmonella typhimurium. The mutants were isolated by using positive selection by chlorpromazine resistance. The physiological and biochemical properties of the lon mutants in S. typhimurium are very similar to those of Escherichia coli lon mutants. Mutants altered at this locus contain little or no activity of the ATP-dependent protease La and show a number of pleiotropic phenotypes, including increased production of capsular polysaccharides, increased sensitivity to UV light and other DNA-damaging agents, and a decreased ability to degrade abnormal proteins.

Original languageEnglish (US)
Pages (from-to)193-197
Number of pages5
JournalJournal of Bacteriology
Issue number1
StatePublished - 1986
Externally publishedYes

ASJC Scopus subject areas

  • Applied Microbiology and Biotechnology
  • Immunology


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