Isolated hearts from obese rats show impaired function during hypoxia

L. D. Segel, S. V. Rendig, D. T. Mason, J. S. Stern

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

Cardiac hemodynamic function of genetically obese male Zucker rats and lean male littermates was studied using an isolated ejecting whole heart preparation. Minimal differences in function were observed between hearts from 9-week-old lean and obese rats. In contrast, hearts from 19-week-old obese rats exhibited depressed ventricular function curves accompanied by decreased stroke work, maximum power, and efficiency in hypoxia, and reduced response to dobutamine in hypoxia compared with controls. These findings suggest that chronic severe obesity in the Zucker rat is associated with the development of diminished cardiac resistance to hypoxic stress.

Original languageEnglish (US)
Pages (from-to)111-119
Number of pages9
JournalProceedings of the Society for Experimental Biology and Medicine
Volume163
Issue number1
StatePublished - 1980

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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