Abstract
Isolated extramedullary relapse of chronic myelogenous leukemia (CML) after allogeneic stem cell transplant is rare. A case is reported of a patient who developed a granulocytic sarcoma of the cavernous sinus 7 months after allogeneic transplant for CML. He presented with neurologic deficits, and a mass lesion was found on imaging. No evidence of hematologic relapse was identified by bone marrow histology or cytogenetics. A premortem diagnosis was not possible, and the patient died 2 months later of an intracerebral hemorrhage after receiving various therapies directed against a presumed infectious etiology. Granulocytic sarcoma should be considered in the differential diagnosis of mass lesions presenting after allogeneic transplant for CML, even if there is no evidence of medullary disease.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 108-110 |
| Number of pages | 3 |
| Journal | Annals of Hematology |
| Volume | 81 |
| Issue number | 2 |
| DOIs | |
| State | Published - 2002 |
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Keywords
- Allogeneic stem cell transplant
- Cavernous sinus mass
- Chronic myelogenous leukemia
- Graft-versus-host disease
- Granulocytic sarcoma
ASJC Scopus subject areas
- Hematology
Cite this
Isolated cavernous sinus extramedullary relapse of chronic myelogenous leukemia following allogeneic stem cell transplant. / Martel, C. L.; Reddy, S. K.; Greco, C. M.; Tuscano, Joseph; Richman, Carol M; Wun, Theodore.
In: Annals of Hematology, Vol. 81, No. 2, 2002, p. 108-110.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Isolated cavernous sinus extramedullary relapse of chronic myelogenous leukemia following allogeneic stem cell transplant
AU - Martel, C. L.
AU - Reddy, S. K.
AU - Greco, C. M.
AU - Tuscano, Joseph
AU - Richman, Carol M
AU - Wun, Theodore
PY - 2002
Y1 - 2002
N2 - Isolated extramedullary relapse of chronic myelogenous leukemia (CML) after allogeneic stem cell transplant is rare. A case is reported of a patient who developed a granulocytic sarcoma of the cavernous sinus 7 months after allogeneic transplant for CML. He presented with neurologic deficits, and a mass lesion was found on imaging. No evidence of hematologic relapse was identified by bone marrow histology or cytogenetics. A premortem diagnosis was not possible, and the patient died 2 months later of an intracerebral hemorrhage after receiving various therapies directed against a presumed infectious etiology. Granulocytic sarcoma should be considered in the differential diagnosis of mass lesions presenting after allogeneic transplant for CML, even if there is no evidence of medullary disease.
AB - Isolated extramedullary relapse of chronic myelogenous leukemia (CML) after allogeneic stem cell transplant is rare. A case is reported of a patient who developed a granulocytic sarcoma of the cavernous sinus 7 months after allogeneic transplant for CML. He presented with neurologic deficits, and a mass lesion was found on imaging. No evidence of hematologic relapse was identified by bone marrow histology or cytogenetics. A premortem diagnosis was not possible, and the patient died 2 months later of an intracerebral hemorrhage after receiving various therapies directed against a presumed infectious etiology. Granulocytic sarcoma should be considered in the differential diagnosis of mass lesions presenting after allogeneic transplant for CML, even if there is no evidence of medullary disease.
KW - Allogeneic stem cell transplant
KW - Cavernous sinus mass
KW - Chronic myelogenous leukemia
KW - Graft-versus-host disease
KW - Granulocytic sarcoma
UR - http://www.scopus.com/inward/record.url?scp=0036944425&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0036944425&partnerID=8YFLogxK
U2 - 10.1007/s00277-001-0411-x
DO - 10.1007/s00277-001-0411-x
M3 - Article
C2 - 11907793
AN - SCOPUS:0036944425
VL - 81
SP - 108
EP - 110
JO - Annals of Hematology
JF - Annals of Hematology
SN - 0939-5555
IS - 2
ER -