Isolated cavernous sinus extramedullary relapse of chronic myelogenous leukemia following allogeneic stem cell transplant

C. L. Martel, S. K. Reddy, C. M. Greco, Joseph Tuscano, Carol M Richman, Theodore Wun

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Isolated extramedullary relapse of chronic myelogenous leukemia (CML) after allogeneic stem cell transplant is rare. A case is reported of a patient who developed a granulocytic sarcoma of the cavernous sinus 7 months after allogeneic transplant for CML. He presented with neurologic deficits, and a mass lesion was found on imaging. No evidence of hematologic relapse was identified by bone marrow histology or cytogenetics. A premortem diagnosis was not possible, and the patient died 2 months later of an intracerebral hemorrhage after receiving various therapies directed against a presumed infectious etiology. Granulocytic sarcoma should be considered in the differential diagnosis of mass lesions presenting after allogeneic transplant for CML, even if there is no evidence of medullary disease.

Original languageEnglish (US)
Pages (from-to)108-110
Number of pages3
JournalAnnals of Hematology
Volume81
Issue number2
DOIs
StatePublished - 2002

Fingerprint

Cavernous Sinus
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Myeloid Sarcoma
Stem Cells
Transplants
Recurrence
Cerebral Hemorrhage
Neurologic Manifestations
Cytogenetics
Histology
Differential Diagnosis
Bone Marrow
Therapeutics

Keywords

  • Allogeneic stem cell transplant
  • Cavernous sinus mass
  • Chronic myelogenous leukemia
  • Graft-versus-host disease
  • Granulocytic sarcoma

ASJC Scopus subject areas

  • Hematology

Cite this

Isolated cavernous sinus extramedullary relapse of chronic myelogenous leukemia following allogeneic stem cell transplant. / Martel, C. L.; Reddy, S. K.; Greco, C. M.; Tuscano, Joseph; Richman, Carol M; Wun, Theodore.

In: Annals of Hematology, Vol. 81, No. 2, 2002, p. 108-110.

Research output: Contribution to journalArticle

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AU - Richman, Carol M

AU - Wun, Theodore

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