Isolated adrenocorticotrophic hormone (ACTH) deficiency associated with acute adrenal crisis

I. Jiala, R. K. Desai, I. C. Maharaj, A. S. Pala, S. M. Joubert

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


A 37 year old black female presented with congestive cardiac failure, 2 months postpartum. She developed spontaneous hypoglycaemia and symptoms of acute adrenal crisis (hypotension, nausea, abdominal pain and tachycardiawith small thready pulse), which responded to i.v. dextrose, sodium chloride and hydrocortisone. Biochemical investigations revealed low serum cortisol and plasma adrenocorticotrophic hormone (ACTH) levels. The patient initially showed an impaired cortisol response to intramuscular aqueous tetracosactrin, but an exuberant response after priming with intramuscular tetracosactrin depot. These findings, together with the normal remainiing pituitary function, led us to conclude that this patient had isolated ACTH deficiencyassociated with congestive cardiac failure and acute adrenal crisis.

Original languageEnglish (US)
Pages (from-to)423-425
Number of pages3
JournalPostgraduate Medical Journal
Issue number715
StatePublished - 1985
Externally publishedYes

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Epidemiology
  • Medicine(all)


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