Isoflurane depresses electroencephalographic and medial thalamic responses to noxious stimulation via an indirect spinal action

Joseph F. Antognini, Earl Carstens, Makoto Sudo, Satoko Sudo

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Anesthetics such as isoflurane act in the spinal cord to suppress movement in response to noxious stimulation. Spinal anesthesia decreases hypnotic/sedative requirements, possibly by decreasing afferent transmission of stimuli. We hypothesized that isoflurane action in the spinal cord would similarly depress the ascending transmission of noxious input to the thalamus and cerebral cortex. In six isoflurane-anesthetized goats, we measured electroencephalographic (EEG) and thalamic single-unit responses to a clamp applied to the forelimb. Cranial bypass permitted differential isoflurane delivery to the torso and cranial circulations. When the cranial-torso isoflurane combination was 1.3% ± 0.2%-1.0% ± 0.4% the noxious stimulus did not evoke significant changes in the EEG or thalamic activity: 389 (153-544) to 581 (172-726) impulses/min, (median, 25th-75th percentile range, P > 0.05). When the cranial-torso isoflurane combination was 1.3% ± 0.2%-0.3% ± 0.2%, noxious stimulation increased thalamic activity: 804 (366-1162) to 1124 (766-1865) impulses/min (P < 0.05), and the EEG 'desynchronized': total EEG power decreased from 25 ± 20 μV2 to 12 ± 8 μV2 (P < 0.05). When the cranial-torso isoflurane was 1.7% ± 0.1%-0.3% ± 0.2%, the noxious stimulus did not significantly affect thalamic: 576 (187-738) to 1031 (340-1442) impulses/min (P > 0.05), or EEG activity. The indirect torso effect of isoflurane on evoked EEG total power (12.6 ± 2.7 μV2/vol%, mean ± SE) was quantitatively similar to the direct cranial effect (17.7 ± 3.0 μV2/vol%; P > 0.05). These data suggest that isoflurane acts in the spinal cord to blunt the transmission of noxious inputs to the thalamus and cerebral cortex, and thus might indirectly contribute to anesthetic endpoints such as amnesia and unconsciousness.

Original languageEnglish (US)
Pages (from-to)1282-1288
Number of pages7
JournalAnesthesia and Analgesia
Volume91
Issue number5
StatePublished - 2000

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Isoflurane
Torso
Spinal Cord
Thalamus
Cerebral Cortex
Anesthetics
Amnesia
Unconsciousness
Forelimb
Spinal Anesthesia
Hypnotics and Sedatives
Goats

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

Cite this

Isoflurane depresses electroencephalographic and medial thalamic responses to noxious stimulation via an indirect spinal action. / Antognini, Joseph F.; Carstens, Earl; Sudo, Makoto; Sudo, Satoko.

In: Anesthesia and Analgesia, Vol. 91, No. 5, 2000, p. 1282-1288.

Research output: Contribution to journalArticle

Antognini, Joseph F. ; Carstens, Earl ; Sudo, Makoto ; Sudo, Satoko. / Isoflurane depresses electroencephalographic and medial thalamic responses to noxious stimulation via an indirect spinal action. In: Anesthesia and Analgesia. 2000 ; Vol. 91, No. 5. pp. 1282-1288.
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