Ischemic stroke biomarkers in blood

Lena Rothstein, Glen C. Jickling

Research output: Contribution to journalArticle

35 Scopus citations

Abstract

Ischemic stroke is a leading cause of adult disability and mortality. With over 15 million strokes occurring every year in the world, methods to better identify patients at risk for stroke are needed, as are methods to improve patient diagnosis and prognosis when stroke occurs. Use of blood-based biomarkers is one method that has been evaluated to predict risk of stroke, diagnose stroke and its causes, predict stroke severity and outcome, and guide prevention therapy. Markers that have been identified include a variety of proteins, nucleic acids and lipids that relate to stroke pathophysiology. The role of blood biomarkers in ischemic stroke is still being defined, and further study is needed to develop blood biomarkers for clinical stroke use. In this review, the authors provide a summary of biomarkers that have been divided by their potential clinical application.

Original languageEnglish (US)
Pages (from-to)37-47
Number of pages11
JournalBiomarkers in Medicine
Volume7
Issue number1
DOIs
StatePublished - Feb 2013

Keywords

  • biomarkers
  • blood
  • gene expression
  • ischemic stroke

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Biochemistry, medical
  • Drug Discovery

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