Ischemia potentiates the reflex bronchodilation evoked by static muscular contraction in dogs

Philip A. Padrid, James R. Haselton, Marc P Kaufman

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

In eleven anesthetized dogs, we found that static contraction of hindlimb muscles that were freely perfused decreased total lung resistance by 0.7 ± 0.1 cm H2O·L-1·sec, whereas static contraction of the same muscles rendered ischemic decreased total lung resistance by 1.5±0.4 cm H2O·L-1·sec (P < 0.025). In ten other dogs, we found that static contraction of freely perfused hindlimb muscles decreased total lung resistance by 0.9 ± 0.2 cm H2O·L-1·sec, whereas dynamic contraction of the same freely perfused muscles decreased total lung resistance by 1.1 ± 0.3 cm H2O·L-1·sec. The difference in the magnitudes of the bronchodilator responses of the two modes of contraction was not significant (P > 0.05). We conclude that a mismatch between blood supply and demand in working skeletal muscle increases the reflex bronchodilator response to static contraction. We also conclude that dynamic contraction evokes a reflex bronchodilation equivalent to that evoked by static contraction provided that the tension produced by the two modes of contraction are equal.

Original languageEnglish (US)
Pages (from-to)51-61
Number of pages11
JournalRespiration Physiology
Volume81
Issue number1
DOIs
StatePublished - 1990

Fingerprint

Muscle Contraction
Reflex
Ischemia
Dogs
Lung
Bronchodilator Agents
Hindlimb
Skeletal Muscle

Keywords

  • Airway resistance, and exercise
  • Airway smooth muscle, control of -
  • Animal, dog
  • Bronchodilation
  • Exercise, and airway resistance

ASJC Scopus subject areas

  • Physiology
  • Pulmonary and Respiratory Medicine

Cite this

Ischemia potentiates the reflex bronchodilation evoked by static muscular contraction in dogs. / Padrid, Philip A.; Haselton, James R.; Kaufman, Marc P.

In: Respiration Physiology, Vol. 81, No. 1, 1990, p. 51-61.

Research output: Contribution to journalArticle

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AB - In eleven anesthetized dogs, we found that static contraction of hindlimb muscles that were freely perfused decreased total lung resistance by 0.7 ± 0.1 cm H2O·L-1·sec, whereas static contraction of the same muscles rendered ischemic decreased total lung resistance by 1.5±0.4 cm H2O·L-1·sec (P < 0.025). In ten other dogs, we found that static contraction of freely perfused hindlimb muscles decreased total lung resistance by 0.9 ± 0.2 cm H2O·L-1·sec, whereas dynamic contraction of the same freely perfused muscles decreased total lung resistance by 1.1 ± 0.3 cm H2O·L-1·sec. The difference in the magnitudes of the bronchodilator responses of the two modes of contraction was not significant (P > 0.05). We conclude that a mismatch between blood supply and demand in working skeletal muscle increases the reflex bronchodilator response to static contraction. We also conclude that dynamic contraction evokes a reflex bronchodilation equivalent to that evoked by static contraction provided that the tension produced by the two modes of contraction are equal.

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