Isavuconazole in the treatment of coccidioidal meningitis

Arash Heidari, Miriam Quinlan, David J. Benjamin, Brett Laurence, Anandit Mu, Tiffany Ngai, Wes J. Hoffman, Stuart H Cohen, Ian Howard Mchardy, Royce Johnson, George Richard Thompson

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Patients with coccidioidal meningitis require lifelong antifungal therapy. Cumulative toxicity and lack of antifungal efficacy require salvage therapy in the treatment of some patients. In a retrospective review of nine patients with coccidioidal meningitis treated with isavuconazole, successful therapy was seen in three patients and stable disease was confirmed in six patients. Isavuconazole may be a useful addition to the therapeutic choices currently available for coccidioidal meningitis.

Original languageEnglish (US)
Article numbere02232-18
JournalAntimicrobial Agents and Chemotherapy
DOIs
StatePublished - Mar 1 2019

Keywords

  • Coccidioides
  • Isavuconazole
  • Meningitis

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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  • Cite this

    Heidari, A., Quinlan, M., Benjamin, D. J., Laurence, B., Mu, A., Ngai, T., Hoffman, W. J., Cohen, S. H., Mchardy, I. H., Johnson, R., & Thompson, G. R. (2019). Isavuconazole in the treatment of coccidioidal meningitis. Antimicrobial Agents and Chemotherapy, [e02232-18]. https://doi.org/10.1128/AAC.02232-18