Isavuconazole in the treatment of coccidioidal meningitis

Arash Heidari, Miriam Quinlan, David J. Benjamin, Brett Laurence, Anandit Mu, Tiffany Ngai, Wes J. Hoffman, Stuart H Cohen, Ian Howard Mchardy, Royce Johnson, George Richard Thompson

Research output: Contribution to journal › Article

3 Citations (Scopus)

Abstract

Patients with coccidioidal meningitis require lifelong antifungal therapy. Cumulative toxicity and lack of antifungal efficacy require salvage therapy in the treatment of some patients. In a retrospective review of nine patients with coccidioidal meningitis treated with isavuconazole, successful therapy was seen in three patients and stable disease was confirmed in six patients. Isavuconazole may be a useful addition to the therapeutic choices currently available for coccidioidal meningitis.

Original languageEnglish (US)
Article numbere02232-18
JournalAntimicrobial Agents and Chemotherapy
DOIs
StatePublished - Mar 1 2019

Fingerprint

Meningitis
Therapeutics
Salvage Therapy
isavuconazole

Keywords

  • Coccidioides
  • Isavuconazole
  • Meningitis

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

Cite this

Heidari, A., Quinlan, M., Benjamin, D. J., Laurence, B., Mu, A., Ngai, T., ... Thompson, G. R. (2019). Isavuconazole in the treatment of coccidioidal meningitis. Antimicrobial Agents and Chemotherapy, [e02232-18]. https://doi.org/10.1128/AAC.02232-18

Isavuconazole in the treatment of coccidioidal meningitis. / Heidari, Arash; Quinlan, Miriam; Benjamin, David J.; Laurence, Brett; Mu, Anandit; Ngai, Tiffany; Hoffman, Wes J.; Cohen, Stuart H; Mchardy, Ian Howard; Johnson, Royce; Thompson, George Richard.

In: Antimicrobial Agents and Chemotherapy, 01.03.2019.

Research output: Contribution to journal › Article

Heidari, A, Quinlan, M, Benjamin, DJ, Laurence, B, Mu, A, Ngai, T, Hoffman, WJ, Cohen, SH, Mchardy, IH, Johnson, R & Thompson, GR 2019, 'Isavuconazole in the treatment of coccidioidal meningitis', Antimicrobial Agents and Chemotherapy. https://doi.org/10.1128/AAC.02232-18
Heidari A, Quinlan M, Benjamin DJ, Laurence B, Mu A, Ngai T et al. Isavuconazole in the treatment of coccidioidal meningitis. Antimicrobial Agents and Chemotherapy. 2019 Mar 1. e02232-18. https://doi.org/10.1128/AAC.02232-18
Heidari, Arash ; Quinlan, Miriam ; Benjamin, David J. ; Laurence, Brett ; Mu, Anandit ; Ngai, Tiffany ; Hoffman, Wes J. ; Cohen, Stuart H ; Mchardy, Ian Howard ; Johnson, Royce ; Thompson, George Richard. / Isavuconazole in the treatment of coccidioidal meningitis. In: Antimicrobial Agents and Chemotherapy. 2019.
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