Isavuconazole in the treatment of coccidioidal meningitis

Arash Heidari; Miriam Quinlan; David J. Benjamin; Brett Laurence; Anandit Mu; Tiffany Ngai; Wes J. Hoffman; Stuart H. Cohen; Ian McHardy; Royce Johnson; George R. Thompson

doi:10.1128/AAC.02232-18

Isavuconazole in the treatment of coccidioidal meningitis

Arash Heidari, Miriam Quinlan, David J. Benjamin, Brett Laurence, Anandit Mu, Tiffany Ngai, Wes J. Hoffman, Stuart H. Cohen, Ian McHardy, Royce Johnson, George R. Thompson

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

Patients with coccidioidal meningitis require lifelong antifungal therapy. Cumulative toxicity and lack of antifungal efficacy require salvage therapy in the treatment of some patients. In a retrospective review of nine patients with coccidioidal meningitis treated with isavuconazole, successful therapy was seen in three patients and stable disease was confirmed in six patients. Isavuconazole may be a useful addition to the therapeutic choices currently available for coccidioidal meningitis.

Original language	English (US)
Article number	e02232-18
Journal	Antimicrobial Agents and Chemotherapy
DOIs	https://doi.org/10.1128/AAC.02232-18
State	Published - Mar 1 2019

Keywords

Coccidioides
Isavuconazole
Meningitis

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)
Infectious Diseases

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10.1128/AAC.02232-18

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title = "Isavuconazole in the treatment of coccidioidal meningitis",

abstract = "Patients with coccidioidal meningitis require lifelong antifungal therapy. Cumulative toxicity and lack of antifungal efficacy require salvage therapy in the treatment of some patients. In a retrospective review of nine patients with coccidioidal meningitis treated with isavuconazole, successful therapy was seen in three patients and stable disease was confirmed in six patients. Isavuconazole may be a useful addition to the therapeutic choices currently available for coccidioidal meningitis.",

keywords = "Coccidioides, Isavuconazole, Meningitis",

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T1 - Isavuconazole in the treatment of coccidioidal meningitis

AU - Heidari, Arash

AU - Quinlan, Miriam

AU - Benjamin, David J.

AU - Laurence, Brett

AU - Mu, Anandit

AU - Ngai, Tiffany

AU - Hoffman, Wes J.

AU - Cohen, Stuart H.

AU - McHardy, Ian

AU - Johnson, Royce

AU - Thompson, George R.

PY - 2019/3/1

Y1 - 2019/3/1

N2 - Patients with coccidioidal meningitis require lifelong antifungal therapy. Cumulative toxicity and lack of antifungal efficacy require salvage therapy in the treatment of some patients. In a retrospective review of nine patients with coccidioidal meningitis treated with isavuconazole, successful therapy was seen in three patients and stable disease was confirmed in six patients. Isavuconazole may be a useful addition to the therapeutic choices currently available for coccidioidal meningitis.

AB - Patients with coccidioidal meningitis require lifelong antifungal therapy. Cumulative toxicity and lack of antifungal efficacy require salvage therapy in the treatment of some patients. In a retrospective review of nine patients with coccidioidal meningitis treated with isavuconazole, successful therapy was seen in three patients and stable disease was confirmed in six patients. Isavuconazole may be a useful addition to the therapeutic choices currently available for coccidioidal meningitis.

KW - Coccidioides

KW - Isavuconazole

KW - Meningitis

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ER -

Isavuconazole in the treatment of coccidioidal meningitis

Abstract

Keywords

ASJC Scopus subject areas

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