Isavuconazole in the treatment of coccidioidal meningitis

Arash Heidari, Miriam Quinlan, David J. Benjamin, Brett Laurence, Anandit Mu, Tiffany Ngai, Wes J. Hoffman, Stuart H Cohen, Ian Howard Mchardy, Royce Johnson, George Richard Thompson

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Patients with coccidioidal meningitis require lifelong antifungal therapy. Cumulative toxicity and lack of antifungal efficacy require salvage therapy in the treatment of some patients. In a retrospective review of nine patients with coccidioidal meningitis treated with isavuconazole, successful therapy was seen in three patients and stable disease was confirmed in six patients. Isavuconazole may be a useful addition to the therapeutic choices currently available for coccidioidal meningitis.

Original languageEnglish (US)
Article numbere02232-18
JournalAntimicrobial Agents and Chemotherapy
DOIs
StatePublished - Mar 1 2019

Fingerprint

Meningitis
Therapeutics
Salvage Therapy
isavuconazole

Keywords

  • Coccidioides
  • Isavuconazole
  • Meningitis

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

Cite this

Isavuconazole in the treatment of coccidioidal meningitis. / Heidari, Arash; Quinlan, Miriam; Benjamin, David J.; Laurence, Brett; Mu, Anandit; Ngai, Tiffany; Hoffman, Wes J.; Cohen, Stuart H; Mchardy, Ian Howard; Johnson, Royce; Thompson, George Richard.

In: Antimicrobial Agents and Chemotherapy, 01.03.2019.

Research output: Contribution to journalArticle

Heidari A, Quinlan M, Benjamin DJ, Laurence B, Mu A, Ngai T et al. Isavuconazole in the treatment of coccidioidal meningitis. Antimicrobial Agents and Chemotherapy. 2019 Mar 1. e02232-18. https://doi.org/10.1128/AAC.02232-18
Heidari, Arash ; Quinlan, Miriam ; Benjamin, David J. ; Laurence, Brett ; Mu, Anandit ; Ngai, Tiffany ; Hoffman, Wes J. ; Cohen, Stuart H ; Mchardy, Ian Howard ; Johnson, Royce ; Thompson, George Richard. / Isavuconazole in the treatment of coccidioidal meningitis. In: Antimicrobial Agents and Chemotherapy. 2019.
@article{b5c5dac61ea7459cac3f224356b1b119,
title = "Isavuconazole in the treatment of coccidioidal meningitis",
abstract = "Patients with coccidioidal meningitis require lifelong antifungal therapy. Cumulative toxicity and lack of antifungal efficacy require salvage therapy in the treatment of some patients. In a retrospective review of nine patients with coccidioidal meningitis treated with isavuconazole, successful therapy was seen in three patients and stable disease was confirmed in six patients. Isavuconazole may be a useful addition to the therapeutic choices currently available for coccidioidal meningitis.",
keywords = "Coccidioides, Isavuconazole, Meningitis",
author = "Arash Heidari and Miriam Quinlan and Benjamin, {David J.} and Brett Laurence and Anandit Mu and Tiffany Ngai and Hoffman, {Wes J.} and Cohen, {Stuart H} and Mchardy, {Ian Howard} and Royce Johnson and Thompson, {George Richard}",
year = "2019",
month = "3",
day = "1",
doi = "10.1128/AAC.02232-18",
language = "English (US)",
journal = "Antimicrobial Agents and Chemotherapy",
issn = "0066-4804",
publisher = "American Society for Microbiology",

}

TY - JOUR

T1 - Isavuconazole in the treatment of coccidioidal meningitis

AU - Heidari, Arash

AU - Quinlan, Miriam

AU - Benjamin, David J.

AU - Laurence, Brett

AU - Mu, Anandit

AU - Ngai, Tiffany

AU - Hoffman, Wes J.

AU - Cohen, Stuart H

AU - Mchardy, Ian Howard

AU - Johnson, Royce

AU - Thompson, George Richard

PY - 2019/3/1

Y1 - 2019/3/1

N2 - Patients with coccidioidal meningitis require lifelong antifungal therapy. Cumulative toxicity and lack of antifungal efficacy require salvage therapy in the treatment of some patients. In a retrospective review of nine patients with coccidioidal meningitis treated with isavuconazole, successful therapy was seen in three patients and stable disease was confirmed in six patients. Isavuconazole may be a useful addition to the therapeutic choices currently available for coccidioidal meningitis.

AB - Patients with coccidioidal meningitis require lifelong antifungal therapy. Cumulative toxicity and lack of antifungal efficacy require salvage therapy in the treatment of some patients. In a retrospective review of nine patients with coccidioidal meningitis treated with isavuconazole, successful therapy was seen in three patients and stable disease was confirmed in six patients. Isavuconazole may be a useful addition to the therapeutic choices currently available for coccidioidal meningitis.

KW - Coccidioides

KW - Isavuconazole

KW - Meningitis

UR - http://www.scopus.com/inward/record.url?scp=85062282971&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85062282971&partnerID=8YFLogxK

U2 - 10.1128/AAC.02232-18

DO - 10.1128/AAC.02232-18

M3 - Article

C2 - 30559134

AN - SCOPUS:85062282971

JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

SN - 0066-4804

M1 - e02232-18

ER -