Isavuconazole in the treatment of coccidioidal meningitis

Arash Heidari; Miriam Quinlan; David J. Benjamin; Brett Laurence; Anandit Mu; Tiffany Ngai; Wes J. Hoffman; Stuart H Cohen; Ian Howard Mchardy; Royce Johnson; George Richard Thompson

doi:10.1128/AAC.02232-18

Isavuconazole in the treatment of coccidioidal meningitis

Arash Heidari, Miriam Quinlan, David J. Benjamin, Brett Laurence, Anandit Mu, Tiffany Ngai, Wes J. Hoffman, Stuart H Cohen, Ian Howard Mchardy, Royce Johnson, George Richard Thompson

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Patients with coccidioidal meningitis require lifelong antifungal therapy. Cumulative toxicity and lack of antifungal efficacy require salvage therapy in the treatment of some patients. In a retrospective review of nine patients with coccidioidal meningitis treated with isavuconazole, successful therapy was seen in three patients and stable disease was confirmed in six patients. Isavuconazole may be a useful addition to the therapeutic choices currently available for coccidioidal meningitis.

Original language	English (US)
Article number	e02232-18
Journal	Antimicrobial Agents and Chemotherapy
DOIs	https://doi.org/10.1128/AAC.02232-18
State	Published - Mar 1 2019

Keywords

Coccidioides
Isavuconazole
Meningitis

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)
Infectious Diseases

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10.1128/AAC.02232-18

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Isavuconazole in the treatment of coccidioidal meningitis. / Heidari, Arash; Quinlan, Miriam; Benjamin, David J.; Laurence, Brett; Mu, Anandit; Ngai, Tiffany; Hoffman, Wes J.; Cohen, Stuart H ; Mchardy, Ian Howard; Johnson, Royce; Thompson, George Richard.

In: Antimicrobial Agents and Chemotherapy, 01.03.2019.

Research output: Contribution to journal › Article › peer-review

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AU - Ngai, Tiffany

AU - Hoffman, Wes J.

AU - Cohen, Stuart H

AU - Mchardy, Ian Howard

AU - Johnson, Royce

AU - Thompson, George Richard

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AB - Patients with coccidioidal meningitis require lifelong antifungal therapy. Cumulative toxicity and lack of antifungal efficacy require salvage therapy in the treatment of some patients. In a retrospective review of nine patients with coccidioidal meningitis treated with isavuconazole, successful therapy was seen in three patients and stable disease was confirmed in six patients. Isavuconazole may be a useful addition to the therapeutic choices currently available for coccidioidal meningitis.

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Isavuconazole in the treatment of coccidioidal meningitis

Abstract

Keywords

ASJC Scopus subject areas

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