Abstract
Background: The tuberculin skin test (TST) is the most commonly used tool to detect infection with Mycobacterium tuberculosis. We sought to determine whether tuberculin skin testing is useful to detect latent infection by M. tuberculosis in a population that was vaccinated with the Bacille Calmette Guérin (BCG) vaccine. Methods: We performeda cross-sectional study during October 2000-February 2001, enrolling first and sixth graders from a random, stratified sample of public elementary schools in Orizaba, Veracruz, Mexico. We assessed the relationship between sociodemographic and epidemiological information, BCG scars, and TST reactivity. Results: There were 858 children enrolled in the study with a completed questionnaire and TST result. The prevalence of a positive TST result (≥10 mm) was 12.4%. Controlling for BCG scar, age, and other characteristics, close contact with pulmonary tuberculosis patients (odds ratio 6.56, 95% confidence interval 2.05 - 21.07, P = 0.001) was independently associated with TST reactivity. Conclusions: TST results helped identify children in a BCG-vaccinated population who had recent exposure to persons with pulmonary tuberculosis, were probably infected with M. tuberculosis, and could benefit from treatment for their latent tuberculosis infection.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1447-1454 |
| Number of pages | 8 |
| Journal | International Journal of Epidemiology |
| Volume | 35 |
| Issue number | 6 |
| DOIs | |
| State | Published - Dec 2006 |
| Externally published | Yes |
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Keywords
- Bacille Calmette Guérin (BCG) vaccine
- Latent infection
- Mycobacterium tuberculosis
- Tuberculin skin test
ASJC Scopus subject areas
- Epidemiology
Cite this
Is tuberculin skin testing useful to diagnose latent tuberculosis in BCG-vaccinated children? / García-Sancho, Ma Cecilia; García-García, Lourdes; Jiménez-Corona, Ma Eugenia; Palacios-Martínez, Manuel; Ferreyra-Reyes, Leticia D.; Canizales-Quintero, Sergio; Cano-Arellano, Bulmaro; Ponce-de-León, Alfredo; Sifuentes-Osornio, José; Small, Peter; DeRiemer, Kathryn.
In: International Journal of Epidemiology, Vol. 35, No. 6, 12.2006, p. 1447-1454.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Is tuberculin skin testing useful to diagnose latent tuberculosis in BCG-vaccinated children?
AU - García-Sancho, Ma Cecilia
AU - García-García, Lourdes
AU - Jiménez-Corona, Ma Eugenia
AU - Palacios-Martínez, Manuel
AU - Ferreyra-Reyes, Leticia D.
AU - Canizales-Quintero, Sergio
AU - Cano-Arellano, Bulmaro
AU - Ponce-de-León, Alfredo
AU - Sifuentes-Osornio, José
AU - Small, Peter
AU - DeRiemer, Kathryn
PY - 2006/12
Y1 - 2006/12
N2 - Background: The tuberculin skin test (TST) is the most commonly used tool to detect infection with Mycobacterium tuberculosis. We sought to determine whether tuberculin skin testing is useful to detect latent infection by M. tuberculosis in a population that was vaccinated with the Bacille Calmette Guérin (BCG) vaccine. Methods: We performeda cross-sectional study during October 2000-February 2001, enrolling first and sixth graders from a random, stratified sample of public elementary schools in Orizaba, Veracruz, Mexico. We assessed the relationship between sociodemographic and epidemiological information, BCG scars, and TST reactivity. Results: There were 858 children enrolled in the study with a completed questionnaire and TST result. The prevalence of a positive TST result (≥10 mm) was 12.4%. Controlling for BCG scar, age, and other characteristics, close contact with pulmonary tuberculosis patients (odds ratio 6.56, 95% confidence interval 2.05 - 21.07, P = 0.001) was independently associated with TST reactivity. Conclusions: TST results helped identify children in a BCG-vaccinated population who had recent exposure to persons with pulmonary tuberculosis, were probably infected with M. tuberculosis, and could benefit from treatment for their latent tuberculosis infection.
AB - Background: The tuberculin skin test (TST) is the most commonly used tool to detect infection with Mycobacterium tuberculosis. We sought to determine whether tuberculin skin testing is useful to detect latent infection by M. tuberculosis in a population that was vaccinated with the Bacille Calmette Guérin (BCG) vaccine. Methods: We performeda cross-sectional study during October 2000-February 2001, enrolling first and sixth graders from a random, stratified sample of public elementary schools in Orizaba, Veracruz, Mexico. We assessed the relationship between sociodemographic and epidemiological information, BCG scars, and TST reactivity. Results: There were 858 children enrolled in the study with a completed questionnaire and TST result. The prevalence of a positive TST result (≥10 mm) was 12.4%. Controlling for BCG scar, age, and other characteristics, close contact with pulmonary tuberculosis patients (odds ratio 6.56, 95% confidence interval 2.05 - 21.07, P = 0.001) was independently associated with TST reactivity. Conclusions: TST results helped identify children in a BCG-vaccinated population who had recent exposure to persons with pulmonary tuberculosis, were probably infected with M. tuberculosis, and could benefit from treatment for their latent tuberculosis infection.
KW - Bacille Calmette Guérin (BCG) vaccine
KW - Latent infection
KW - Mycobacterium tuberculosis
KW - Tuberculin skin test
UR - http://www.scopus.com/inward/record.url?scp=33846645435&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33846645435&partnerID=8YFLogxK
U2 - 10.1093/ije/dyl213
DO - 10.1093/ije/dyl213
M3 - Article
C2 - 17008360
AN - SCOPUS:33846645435
VL - 35
SP - 1447
EP - 1454
JO - International Journal of Epidemiology
JF - International Journal of Epidemiology
SN - 0300-5771
IS - 6
ER -