Is Tissue Engineering Helping Orthopaedic Care in Trauma?

Brett D. Crist, Jonathan K Leach, Mark A Lee

Research output: Contribution to journalArticle

Abstract

Tissue engineering in orthopaedic trauma is needed. Progress has been made in all areas including regenerating bone, cartilage, soft tissue, and making up for bone defects with scaffolds. Bone regeneration and managing bone defects with scaffolds continue to be successful in the basic science realm with promising results, but currently, these successes are mostly limited to small animal models. Cartilage defects have more clinically available treatment options, but the benefits of "off-the-shelf" allograft options, and scaffolds, have little clinical evidence in the acute fracture setting. Most of the true chondrocyte replacement therapies such as matrix-induced autologous chondrocyte implantation and osteochondral allografts require delayed treatment while cell growth or graft matching occurs. Soft-tissue defects can be managed with tissue engineering for the skin with success, but muscle and nerve defects are still limited to the basic science arena. Although significant gains have been made in all areas for tissue engineering in basic science, and is very promising, this success currently comes with limited translation into clinical availability for the orthopaedic trauma patient.

Original languageEnglish (US)
Pages (from-to)S12-S19
JournalJournal of orthopaedic trauma
Volume33
DOIs
StatePublished - Jun 1 2019

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Tissue Engineering
Orthopedics
Chondrocytes
Bone and Bones
Cartilage
Allografts
Wounds and Injuries
Bone Regeneration
Therapeutics
Animal Models
Transplants
Muscles
Skin
Growth

ASJC Scopus subject areas

  • Surgery
  • Orthopedics and Sports Medicine

Cite this

Is Tissue Engineering Helping Orthopaedic Care in Trauma? / Crist, Brett D.; Leach, Jonathan K; Lee, Mark A.

In: Journal of orthopaedic trauma, Vol. 33, 01.06.2019, p. S12-S19.

Research output: Contribution to journalArticle

Crist, Brett D. ; Leach, Jonathan K ; Lee, Mark A. / Is Tissue Engineering Helping Orthopaedic Care in Trauma?. In: Journal of orthopaedic trauma. 2019 ; Vol. 33. pp. S12-S19.
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