Is there convergence of gut microbes in blood-feeding vertebrates?

Se Jin Song, Jon G. Sanders, Daniel T. Baldassarre, Jaime A. Chaves, Nicholas S. Johnson, Antoinette J. Piaggio, Matthew J. Stuckey, Eva Nováková, Jessica L. Metcalf, Bruno B Chomel, Alvaro Aguilar-Setién, Rob Knight, Valerie J. McKenzie

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Animal microbiomes play an important role in dietary adaptation, yet the extent to which microbiome changes exhibit parallel evolution is unclear. Of particular interest is an adaptation to extreme diets, such as blood, which poses special challenges in its content of proteins and lack of essential nutrients. In this study, we assessed taxonomic signatures (by 16S rRNA amplicon profiling) and potential functional signatures (inferred by Phylogenetic Investigation of Communities by Reconstruction of Unobserved States (PICRUSt)) of haematophagy in birds and bats. Our goal was to test three alternative hypotheses: no convergence of microbiomes, convergence in taxonomy and convergence in function. We find a statistically significant effect of haematophagy in terms of microbial taxonomic convergence across the blood-feeding bats and birds, although this effect is small compared to the differences found between haematophagous and non-haematophagous species within the two host clades. We also find some evidence of convergence at the predicted functional level, although it is possible that the lack of metagenomic data and the poor representation of microbial lineages adapted to haematophagy in genome databases limit the power of this approach. The results provide a paradigm for exploring convergent microbiome evolution replicated with independent contrasts in different host lineages. This article is part of the theme issue 'Convergent evolution in the genomics era: new insights and directions'.

Original languageEnglish (US)
Article number20180249
JournalPhilosophical Transactions of the Royal Society B: Biological Sciences
Volume374
Issue number1777
DOIs
StatePublished - Jan 1 2019

Fingerprint

Microbiota
Birds
hematophagy
Vertebrates
Blood
digestive system
vertebrates
microorganisms
blood
Taxonomies
Nutrition
Nutrients
Chiroptera
Animals
Genes
Metagenomics
parallel evolution
convergent evolution
birds
Genomics

Keywords

  • Convergence
  • Haematophagy
  • Microbiome

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Song, S. J., Sanders, J. G., Baldassarre, D. T., Chaves, J. A., Johnson, N. S., Piaggio, A. J., ... McKenzie, V. J. (2019). Is there convergence of gut microbes in blood-feeding vertebrates? Philosophical Transactions of the Royal Society B: Biological Sciences, 374(1777), [20180249]. https://doi.org/10.1098/rstb.2018.0249

Is there convergence of gut microbes in blood-feeding vertebrates? / Song, Se Jin; Sanders, Jon G.; Baldassarre, Daniel T.; Chaves, Jaime A.; Johnson, Nicholas S.; Piaggio, Antoinette J.; Stuckey, Matthew J.; Nováková, Eva; Metcalf, Jessica L.; Chomel, Bruno B; Aguilar-Setién, Alvaro; Knight, Rob; McKenzie, Valerie J.

In: Philosophical Transactions of the Royal Society B: Biological Sciences, Vol. 374, No. 1777, 20180249, 01.01.2019.

Research output: Contribution to journalArticle

Song, SJ, Sanders, JG, Baldassarre, DT, Chaves, JA, Johnson, NS, Piaggio, AJ, Stuckey, MJ, Nováková, E, Metcalf, JL, Chomel, BB, Aguilar-Setién, A, Knight, R & McKenzie, VJ 2019, 'Is there convergence of gut microbes in blood-feeding vertebrates?', Philosophical Transactions of the Royal Society B: Biological Sciences, vol. 374, no. 1777, 20180249. https://doi.org/10.1098/rstb.2018.0249
Song, Se Jin ; Sanders, Jon G. ; Baldassarre, Daniel T. ; Chaves, Jaime A. ; Johnson, Nicholas S. ; Piaggio, Antoinette J. ; Stuckey, Matthew J. ; Nováková, Eva ; Metcalf, Jessica L. ; Chomel, Bruno B ; Aguilar-Setién, Alvaro ; Knight, Rob ; McKenzie, Valerie J. / Is there convergence of gut microbes in blood-feeding vertebrates?. In: Philosophical Transactions of the Royal Society B: Biological Sciences. 2019 ; Vol. 374, No. 1777.
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