Is there a 'regressive phenotype' of autism spectrum disorder associated with the measles-mumps-rubella vaccine? A CPEA study

Jennifer Richler, Rhiannon Luyster, Susan Risi, Wan Ling Hsu, Geraldine Dawson, Raphael Bernier, Michelle Dunn, Susan Hepburn, Susan L. Hyman, William M. McMahon, Julie Goudie-Nice, Nancy Minshew, Sally J Rogers, Marian Sigman, M. Anne Spence, Wendy A. Goldberg, Helen Tager-Flusberg, Fred R. Volkmar, Catherine Lord

Research output: Contribution to journalArticle

94 Scopus citations

Abstract

A multi-site study of 351 children with Autism Spectrum Disorders (ASD) and 31 typically developing children used caregiver interviews to describe the children's early acquisition and loss of social-communication milestones. For the majority of children with ASD who had experienced a regression, pre-loss development was clearly atypical. Children who had lost skills also showed slightly poorer outcomes in verbal IQ and social reciprocity, a later mean age of onset of autistic symptoms, and more gastrointestinal symptoms than children with ASD and no regression. There was no evidence that onset of autistic symptoms or of regression was related to measles-mumps-rubella vaccination. The implications of these findings for the existence of a 'regressive phenotype' of ASD are discussed.

Original languageEnglish (US)
Pages (from-to)299-316
Number of pages18
JournalJournal of Autism and Developmental Disorders
Volume36
Issue number3
DOIs
StatePublished - Apr 2006

Keywords

  • Autism Diagnostic Interview - Revised (ADI-R)
  • Autism spectrum disorder
  • Gastrointestinal disorders
  • Language development
  • Measles-mumps-rubella (MMR) vaccine
  • Regression

ASJC Scopus subject areas

  • Psychology(all)
  • Developmental and Educational Psychology

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    Richler, J., Luyster, R., Risi, S., Hsu, W. L., Dawson, G., Bernier, R., Dunn, M., Hepburn, S., Hyman, S. L., McMahon, W. M., Goudie-Nice, J., Minshew, N., Rogers, S. J., Sigman, M., Spence, M. A., Goldberg, W. A., Tager-Flusberg, H., Volkmar, F. R., & Lord, C. (2006). Is there a 'regressive phenotype' of autism spectrum disorder associated with the measles-mumps-rubella vaccine? A CPEA study. Journal of Autism and Developmental Disorders, 36(3), 299-316. https://doi.org/10.1007/s10803-005-0070-1