Is Progressive Chronic Kidney Disease a Slow Acute Kidney Injury?

Larry D Cowgill, David J. Polzin, Jonathan Elliott, Mary B. Nabity, Gilad Segev, Gregory F. Grauer, Scott Brown, Cathy Langston, Astrid M. van Dongen

Research output: Contribution to journalReview articlepeer-review

15 Scopus citations

Abstract

International Renal Interest Society chronic kidney disease Stage 1 and acute kidney injury Grade I categorizations of kidney disease are often confused or ignored because patients are nonazotemic and generally asymptomatic. Recent evidence suggests these seemingly disparate conditions may be mechanistically linked and interrelated. Active kidney injury biomarkers have the potential to establish a new understanding for traditional views of chronic kidney disease, including its early identification and possible mediators of its progression, which, if validated, would establish a new and sophisticated paradigm for the understanding and approach to the diagnostic evaluation, and treatment of urinary disease in dogs and cats.

Original languageEnglish (US)
Pages (from-to)995-1013
Number of pages19
JournalVeterinary Clinics of North America - Small Animal Practice
Volume46
Issue number6
DOIs
StatePublished - Nov 1 2016

Keywords

  • IRIS AKI grade I
  • IRIS CKD stage 1
  • Kidney biomarkers
  • Progressive chronic kidney disease

ASJC Scopus subject areas

  • Small Animals

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