Abstract
We analyzed data from case groups of 538 children with autism spectrum disorders (ASD) and 163 with developmental delays (DD), and from 421 typically developing controls to assess associations with maternal influenza or fever during pregnancy. Exposure information was obtained by telephone interviews, and outcomes were clinically confirmed. Though neither ASD nor DD was associated with influenza, both were associated with maternal fever during pregnancy: OR's (odds ratios) were 2.12 (95 % CI 1.17, 3.84) and 2.50 (95 % CI 1.20, 5.20) respectively. However, the fever-associated ASD risk was attenuated among mothers who reported taking antipyretic medications (OR = 1.30, 95 % CI 0.59, 2.84), but remained elevated for those who did not (OR = 2.55, 95 % CI 1.30, 4.99).
| Original language | English (US) |
|---|---|
| Pages (from-to) | 25-33 |
| Number of pages | 9 |
| Journal | Journal of Autism and Developmental Disorders |
| Volume | 43 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 2013 |
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Keywords
- Anti-fever medication
- Autism
- Fever
- Maternal influenza
ASJC Scopus subject areas
- Developmental and Educational Psychology
Cite this
Is Maternal Influenza or Fever during Pregnancy Associated with Autism or Developmental Delays? Results from the CHARGE (childhood Autism Risks from Genetics and Environment) Study. / Zerbo, Ousseny; Iosif, Ana-Maria; Walker, Cheryl; Ozonoff, Sally J; Hansen, Robin L; Hertz-Picciotto, Irva.
In: Journal of Autism and Developmental Disorders, Vol. 43, No. 1, 01.2013, p. 25-33.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Is Maternal Influenza or Fever during Pregnancy Associated with Autism or Developmental Delays? Results from the CHARGE (childhood Autism Risks from Genetics and Environment) Study
AU - Zerbo, Ousseny
AU - Iosif, Ana-Maria
AU - Walker, Cheryl
AU - Ozonoff, Sally J
AU - Hansen, Robin L
AU - Hertz-Picciotto, Irva
PY - 2013/1
Y1 - 2013/1
N2 - We analyzed data from case groups of 538 children with autism spectrum disorders (ASD) and 163 with developmental delays (DD), and from 421 typically developing controls to assess associations with maternal influenza or fever during pregnancy. Exposure information was obtained by telephone interviews, and outcomes were clinically confirmed. Though neither ASD nor DD was associated with influenza, both were associated with maternal fever during pregnancy: OR's (odds ratios) were 2.12 (95 % CI 1.17, 3.84) and 2.50 (95 % CI 1.20, 5.20) respectively. However, the fever-associated ASD risk was attenuated among mothers who reported taking antipyretic medications (OR = 1.30, 95 % CI 0.59, 2.84), but remained elevated for those who did not (OR = 2.55, 95 % CI 1.30, 4.99).
AB - We analyzed data from case groups of 538 children with autism spectrum disorders (ASD) and 163 with developmental delays (DD), and from 421 typically developing controls to assess associations with maternal influenza or fever during pregnancy. Exposure information was obtained by telephone interviews, and outcomes were clinically confirmed. Though neither ASD nor DD was associated with influenza, both were associated with maternal fever during pregnancy: OR's (odds ratios) were 2.12 (95 % CI 1.17, 3.84) and 2.50 (95 % CI 1.20, 5.20) respectively. However, the fever-associated ASD risk was attenuated among mothers who reported taking antipyretic medications (OR = 1.30, 95 % CI 0.59, 2.84), but remained elevated for those who did not (OR = 2.55, 95 % CI 1.30, 4.99).
KW - Anti-fever medication
KW - Autism
KW - Fever
KW - Maternal influenza
UR - http://www.scopus.com/inward/record.url?scp=84872340331&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84872340331&partnerID=8YFLogxK
U2 - 10.1007/s10803-012-1540-x
DO - 10.1007/s10803-012-1540-x
M3 - Article
C2 - 22562209
AN - SCOPUS:84872340331
VL - 43
SP - 25
EP - 33
JO - Journal of Autism and Developmental Disorders
JF - Journal of Autism and Developmental Disorders
SN - 0162-3257
IS - 1
ER -