Is Maternal Influenza or Fever during Pregnancy Associated with Autism or Developmental Delays? Results from the CHARGE (childhood Autism Risks from Genetics and Environment) Study

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Abstract

We analyzed data from case groups of 538 children with autism spectrum disorders (ASD) and 163 with developmental delays (DD), and from 421 typically developing controls to assess associations with maternal influenza or fever during pregnancy. Exposure information was obtained by telephone interviews, and outcomes were clinically confirmed. Though neither ASD nor DD was associated with influenza, both were associated with maternal fever during pregnancy: OR's (odds ratios) were 2.12 (95 % CI 1.17, 3.84) and 2.50 (95 % CI 1.20, 5.20) respectively. However, the fever-associated ASD risk was attenuated among mothers who reported taking antipyretic medications (OR = 1.30, 95 % CI 0.59, 2.84), but remained elevated for those who did not (OR = 2.55, 95 % CI 1.30, 4.99).

Original languageEnglish (US)
Pages (from-to)25-33
Number of pages9
JournalJournal of Autism and Developmental Disorders
Volume43
Issue number1
DOIs
StatePublished - Jan 2013

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Autistic Disorder
Human Influenza
Fever
Odds Ratio
Mothers
Pregnancy
Antipyretics
Interviews
Autism Spectrum Disorder

Keywords

  • Anti-fever medication
  • Autism
  • Fever
  • Maternal influenza

ASJC Scopus subject areas

  • Developmental and Educational Psychology

Cite this

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title = "Is Maternal Influenza or Fever during Pregnancy Associated with Autism or Developmental Delays? Results from the CHARGE (childhood Autism Risks from Genetics and Environment) Study",
abstract = "We analyzed data from case groups of 538 children with autism spectrum disorders (ASD) and 163 with developmental delays (DD), and from 421 typically developing controls to assess associations with maternal influenza or fever during pregnancy. Exposure information was obtained by telephone interviews, and outcomes were clinically confirmed. Though neither ASD nor DD was associated with influenza, both were associated with maternal fever during pregnancy: OR's (odds ratios) were 2.12 (95 {\%} CI 1.17, 3.84) and 2.50 (95 {\%} CI 1.20, 5.20) respectively. However, the fever-associated ASD risk was attenuated among mothers who reported taking antipyretic medications (OR = 1.30, 95 {\%} CI 0.59, 2.84), but remained elevated for those who did not (OR = 2.55, 95 {\%} CI 1.30, 4.99).",
keywords = "Anti-fever medication, Autism, Fever, Maternal influenza",
author = "Ousseny Zerbo and Ana-Maria Iosif and Cheryl Walker and Ozonoff, {Sally J} and Hansen, {Robin L} and Irva Hertz-Picciotto",
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AU - Zerbo, Ousseny

AU - Iosif, Ana-Maria

AU - Walker, Cheryl

AU - Ozonoff, Sally J

AU - Hansen, Robin L

AU - Hertz-Picciotto, Irva

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N2 - We analyzed data from case groups of 538 children with autism spectrum disorders (ASD) and 163 with developmental delays (DD), and from 421 typically developing controls to assess associations with maternal influenza or fever during pregnancy. Exposure information was obtained by telephone interviews, and outcomes were clinically confirmed. Though neither ASD nor DD was associated with influenza, both were associated with maternal fever during pregnancy: OR's (odds ratios) were 2.12 (95 % CI 1.17, 3.84) and 2.50 (95 % CI 1.20, 5.20) respectively. However, the fever-associated ASD risk was attenuated among mothers who reported taking antipyretic medications (OR = 1.30, 95 % CI 0.59, 2.84), but remained elevated for those who did not (OR = 2.55, 95 % CI 1.30, 4.99).

AB - We analyzed data from case groups of 538 children with autism spectrum disorders (ASD) and 163 with developmental delays (DD), and from 421 typically developing controls to assess associations with maternal influenza or fever during pregnancy. Exposure information was obtained by telephone interviews, and outcomes were clinically confirmed. Though neither ASD nor DD was associated with influenza, both were associated with maternal fever during pregnancy: OR's (odds ratios) were 2.12 (95 % CI 1.17, 3.84) and 2.50 (95 % CI 1.20, 5.20) respectively. However, the fever-associated ASD risk was attenuated among mothers who reported taking antipyretic medications (OR = 1.30, 95 % CI 0.59, 2.84), but remained elevated for those who did not (OR = 2.55, 95 % CI 1.30, 4.99).

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