TY - JOUR
T1 - Is leber hereditary optic neuropathy treatable? Encouraging results with idebenone in both prospective and retrospective trials and an illustrative case
AU - Sabet-Peyman, Esfandiar J.
AU - Khaderi, Khizer R.
AU - Sadun, Alfredo A.
PY - 2012/3
Y1 - 2012/3
N2 - A 31-year-old woman developed subacute bilateral visual loss over a 2-week period. Two months later, the diagnosis of Leber hereditary optic neuropathy (LHON) 11778/ND4 was established and the patient was treated with 900 mg of idebenone daily. Over the ensuing 9 months, visual acuity improved from 20/200 to 20/25 in each eye with near-total resolution in visual field abnormalities. Our case report is in agreement with 2 large published series of patients with LHON treated with idebenone, raising hope for treatment of this visually devastating mitochondrial disorder.
AB - A 31-year-old woman developed subacute bilateral visual loss over a 2-week period. Two months later, the diagnosis of Leber hereditary optic neuropathy (LHON) 11778/ND4 was established and the patient was treated with 900 mg of idebenone daily. Over the ensuing 9 months, visual acuity improved from 20/200 to 20/25 in each eye with near-total resolution in visual field abnormalities. Our case report is in agreement with 2 large published series of patients with LHON treated with idebenone, raising hope for treatment of this visually devastating mitochondrial disorder.
UR - http://www.scopus.com/inward/record.url?scp=84857820970&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84857820970&partnerID=8YFLogxK
U2 - 10.1097/WNO.0b013e318241da45
DO - 10.1097/WNO.0b013e318241da45
M3 - Article
C2 - 22269948
AN - SCOPUS:84857820970
VL - 32
SP - 54
EP - 57
JO - Journal of Clinical Neuro-Ophthalmology
JF - Journal of Clinical Neuro-Ophthalmology
SN - 1070-8022
IS - 1
ER -