Is leber hereditary optic neuropathy treatable? Encouraging results with idebenone in both prospective and retrospective trials and an illustrative case

Esfandiar J. Sabet-Peyman, Khizer R. Khaderi, Alfredo A. Sadun

Research output: Contribution to journalArticlepeer-review

20 Scopus citations

Abstract

A 31-year-old woman developed subacute bilateral visual loss over a 2-week period. Two months later, the diagnosis of Leber hereditary optic neuropathy (LHON) 11778/ND4 was established and the patient was treated with 900 mg of idebenone daily. Over the ensuing 9 months, visual acuity improved from 20/200 to 20/25 in each eye with near-total resolution in visual field abnormalities. Our case report is in agreement with 2 large published series of patients with LHON treated with idebenone, raising hope for treatment of this visually devastating mitochondrial disorder.

Original languageEnglish (US)
Pages (from-to)54-57
Number of pages4
JournalJournal of Neuro-Ophthalmology
Volume32
Issue number1
DOIs
StatePublished - Mar 2012
Externally publishedYes

ASJC Scopus subject areas

  • Clinical Neurology
  • Ophthalmology

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