Is Hepatectomy Justified for BRAF Mutant Colorectal Liver Metastases? A Multi-institutional Analysis of 1497 Patients

Johan Gagnière, Aurélien Dupré, Sepideh S. Gholami, Denis Pezet, Thomas Boerner, Mithat Gönen, Thomas P. Kingham, Peter J. Allen, Vinod P. Balachandran, Ronald P. De Matteo, Jeffrey A. Drebin, Rona Yaeger, Nancy E. Kemeny, William R. Jarnagin, Michael I. D'Angelica

Research output: Contribution to journalArticlepeer-review

32 Scopus citations


Objective: To analyze clinical outcomes and prognostic variables of patients undergoing hepatic resection for BRAF mutant (BRAF-mut) colorectal liver metastases (CRLM). Background: Outcomes following hepatectomy for BRAF-mut CRLM have not been well studied. Methods: All patients who underwent hepatectomy for CRLM with complete resection and known BRAF status during 2001 to 2016 at 3 high-volume centers were analyzed. Results: Of 4124 patients who underwent hepatectomy for CRLM, 1497 had complete resection and known BRAF status. Thirty-five (2%) patients were BRAF-mut, with 71% of V600E mutation. Compared with BRAF wild-type (BRAF-wt), BRAF-mut patients were older, more commonly presented with higher ASA scores, synchronous, multiple and smaller CRLM, underwent more major hepatectomies, but had less extrahepatic disease. Median overall survival (OS) was 81 months for BRAF-wt and 40 months for BRAF-mut patients (P < 0.001). Median recurrence-free survival (RFS) was 22 and 10 months for BRAF-wt and BRAF-mut patients (P < 0.001). For BRAF-mut, factors associated with worse OS were node-positive primary tumor, carcinoembryonic antigen (CEA) >200'μg/L, and clinical risk score (CRS) ≥4. Factors associated with worse RFS were node-positive primary tumor, ≥4 CRLM, and positive hepatic margin. V600E mutations were not associated with worse OS or RFS. A case-control matching analysis on prognostic clinicopathologic factors confirmed shorter OS (P < 0.001) and RFS (P < 0.001) in BRAF-mut.Conclusions: Patients with resectable BRAF-mut CRLM are rare among patients selected for surgery and more commonly present with multiple synchronous tumors. BRAF mutation is associated with worse prognosis; however, long-term survival is possible and associated with node-negative primary tumors, CEA ≤ 200'μg/L and CRS < 4.

Original languageEnglish (US)
Pages (from-to)147-154
Number of pages8
JournalAnnals of Surgery
Issue number1
StatePublished - Jan 1 2020
Externally publishedYes


  • BRAF mutation
  • clinical outcomes
  • colorectal liver metastases
  • hepatectomy
  • liver resection
  • liver surgery
  • metastatic colorectal cancer
  • prognosis

ASJC Scopus subject areas

  • Surgery


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