Is cardiac diagnosis a predictor of neurodevelopmental outcome after cardiac surgery in infancy?

J. William Gaynor, Marsha Gerdes, Alexander Nord, Judy Bernbaum, Elaine Zackai, Gil Wernovsky, Robert R. Clancy, Patrick J. Heagerty, Cynthia B. Solot, Donna McDonald-Mcginn, Gail P. Jarvik

Research output: Contribution to journalArticle

58 Citations (Scopus)

Abstract

Objectives: To determine whether a cardiac diagnosis is a predictor of neurodevelopmental outcomes after infant cardiac surgery. Methods: Infants with ventricular septal defect (VSD), tetralogy of Fallot (TOF), transposition of the great arteries (TGA), and hypoplastic left heart syndrome (HLHS) in a study of apolipoprotein E (APOE) polymorphisms, and neurodevelopmental outcome underwent neurodevelopmental and genetic evaluation at 4 years of age. The domains tested included cognition, language, speech, memory, executive function, visual-motor, fine motor, and reading and math skills. Results: Testing was completed in 178 patients with normal genetic evaluations: VSD (n = 26), TOF (n = 44), TGA (n = 41), and HLHS (n = 67). No differences were found in gestational age, ethnicity, APOE genotype, socioeconomic status, or maternal education among groups. Patient age at the first surgery was significantly lower for patients with TGA and HLHS compared with those with TOF and VSD. The postoperative length of stay was significantly longer for HLHS than all other groups and for TGA compared with TOF and VSD. HLHS correlated significantly with the use of deep hypothermic circulatory arrest and multiple operations. The mean scores for each domain were within normal limits for all groups. Compared with the other patients, those with HLHS had significantly lower scores for cognition, fine motor skills, executive function, and math skills. No significant differences were found among the TGA, TOF or VSD patients for any domain. Significant impairments in at least 1 domain were identified in 8% (2/25) of patients with VSD, 20% (8/41) with TOF, 17% (7/41) with TGA, and 18% (12/65) with HLHS. After correction for the demographic, preoperative, and operative variables, no significant differences were found among the groups for any domain. Conclusions: The mean scores for the neurodevelopmental outcomes domains tested were in the normal range for preschool children with no recognized genetic syndromes after surgery for VSD, TOF, TGA, and HLHS. In each diagnostic group, the number of children with impairments in at least 1 domain increased compared with the general population. Unadjusted neurodevelopmental outcomes for HLHS were lower for cognition, fine motor skills, executive function, and math skills compared with the other patients. After correction for the demographic, preoperative, and operative variables, no significant differences were found among the groups for any domain. The specific cardiac diagnosis determines a large portion of the variation in these covariates. Therefore, although HLHS did predict for poorer outcomes in some domains, it did not add predictive power to the other factors considered.

Original languageEnglish (US)
Pages (from-to)1230-1236
Number of pages7
JournalJournal of Thoracic and Cardiovascular Surgery
Volume140
Issue number6
DOIs
StatePublished - Dec 1 2010
Externally publishedYes

Fingerprint

Hypoplastic Left Heart Syndrome
Thoracic Surgery
Transposition of Great Vessels
Tetralogy of Fallot
Ventricular Heart Septal Defects
Executive Function
Cognition
Motor Skills
Apolipoproteins E
Deep Hypothermia Induced Circulatory Arrest
Demography
Preschool Children
Social Class
Gestational Age
Reading
Length of Stay
Reference Values
Language
Genotype
Mothers

Keywords

  • APOE
  • Apolipoprotein E
  • Cardiopulmonary bypass
  • CHD
  • Congenital heart defect
  • CPB
  • Deep hypothermic circulatory arrest
  • DHCA
  • GFTA
  • Goldman Fristoe Test of Articulation 2
  • HLHS
  • Hypoplastic left heart syndrome
  • ND
  • NEPSY
  • Neurodevelopmental

ASJC Scopus subject areas

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine

Cite this

Is cardiac diagnosis a predictor of neurodevelopmental outcome after cardiac surgery in infancy? / Gaynor, J. William; Gerdes, Marsha; Nord, Alexander; Bernbaum, Judy; Zackai, Elaine; Wernovsky, Gil; Clancy, Robert R.; Heagerty, Patrick J.; Solot, Cynthia B.; McDonald-Mcginn, Donna; Jarvik, Gail P.

In: Journal of Thoracic and Cardiovascular Surgery, Vol. 140, No. 6, 01.12.2010, p. 1230-1236.

Research output: Contribution to journalArticle

Gaynor, JW, Gerdes, M, Nord, A, Bernbaum, J, Zackai, E, Wernovsky, G, Clancy, RR, Heagerty, PJ, Solot, CB, McDonald-Mcginn, D & Jarvik, GP 2010, 'Is cardiac diagnosis a predictor of neurodevelopmental outcome after cardiac surgery in infancy?', Journal of Thoracic and Cardiovascular Surgery, vol. 140, no. 6, pp. 1230-1236. https://doi.org/10.1016/j.jtcvs.2010.07.069
Gaynor, J. William ; Gerdes, Marsha ; Nord, Alexander ; Bernbaum, Judy ; Zackai, Elaine ; Wernovsky, Gil ; Clancy, Robert R. ; Heagerty, Patrick J. ; Solot, Cynthia B. ; McDonald-Mcginn, Donna ; Jarvik, Gail P. / Is cardiac diagnosis a predictor of neurodevelopmental outcome after cardiac surgery in infancy?. In: Journal of Thoracic and Cardiovascular Surgery. 2010 ; Vol. 140, No. 6. pp. 1230-1236.
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abstract = "Objectives: To determine whether a cardiac diagnosis is a predictor of neurodevelopmental outcomes after infant cardiac surgery. Methods: Infants with ventricular septal defect (VSD), tetralogy of Fallot (TOF), transposition of the great arteries (TGA), and hypoplastic left heart syndrome (HLHS) in a study of apolipoprotein E (APOE) polymorphisms, and neurodevelopmental outcome underwent neurodevelopmental and genetic evaluation at 4 years of age. The domains tested included cognition, language, speech, memory, executive function, visual-motor, fine motor, and reading and math skills. Results: Testing was completed in 178 patients with normal genetic evaluations: VSD (n = 26), TOF (n = 44), TGA (n = 41), and HLHS (n = 67). No differences were found in gestational age, ethnicity, APOE genotype, socioeconomic status, or maternal education among groups. Patient age at the first surgery was significantly lower for patients with TGA and HLHS compared with those with TOF and VSD. The postoperative length of stay was significantly longer for HLHS than all other groups and for TGA compared with TOF and VSD. HLHS correlated significantly with the use of deep hypothermic circulatory arrest and multiple operations. The mean scores for each domain were within normal limits for all groups. Compared with the other patients, those with HLHS had significantly lower scores for cognition, fine motor skills, executive function, and math skills. No significant differences were found among the TGA, TOF or VSD patients for any domain. Significant impairments in at least 1 domain were identified in 8{\%} (2/25) of patients with VSD, 20{\%} (8/41) with TOF, 17{\%} (7/41) with TGA, and 18{\%} (12/65) with HLHS. After correction for the demographic, preoperative, and operative variables, no significant differences were found among the groups for any domain. Conclusions: The mean scores for the neurodevelopmental outcomes domains tested were in the normal range for preschool children with no recognized genetic syndromes after surgery for VSD, TOF, TGA, and HLHS. In each diagnostic group, the number of children with impairments in at least 1 domain increased compared with the general population. Unadjusted neurodevelopmental outcomes for HLHS were lower for cognition, fine motor skills, executive function, and math skills compared with the other patients. After correction for the demographic, preoperative, and operative variables, no significant differences were found among the groups for any domain. The specific cardiac diagnosis determines a large portion of the variation in these covariates. Therefore, although HLHS did predict for poorer outcomes in some domains, it did not add predictive power to the other factors considered.",
keywords = "APOE, Apolipoprotein E, Cardiopulmonary bypass, CHD, Congenital heart defect, CPB, Deep hypothermic circulatory arrest, DHCA, GFTA, Goldman Fristoe Test of Articulation 2, HLHS, Hypoplastic left heart syndrome, ND, NEPSY, Neurodevelopmental",
author = "Gaynor, {J. William} and Marsha Gerdes and Alexander Nord and Judy Bernbaum and Elaine Zackai and Gil Wernovsky and Clancy, {Robert R.} and Heagerty, {Patrick J.} and Solot, {Cynthia B.} and Donna McDonald-Mcginn and Jarvik, {Gail P.}",
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TY - JOUR

T1 - Is cardiac diagnosis a predictor of neurodevelopmental outcome after cardiac surgery in infancy?

AU - Gaynor, J. William

AU - Gerdes, Marsha

AU - Nord, Alexander

AU - Bernbaum, Judy

AU - Zackai, Elaine

AU - Wernovsky, Gil

AU - Clancy, Robert R.

AU - Heagerty, Patrick J.

AU - Solot, Cynthia B.

AU - McDonald-Mcginn, Donna

AU - Jarvik, Gail P.

PY - 2010/12/1

Y1 - 2010/12/1

N2 - Objectives: To determine whether a cardiac diagnosis is a predictor of neurodevelopmental outcomes after infant cardiac surgery. Methods: Infants with ventricular septal defect (VSD), tetralogy of Fallot (TOF), transposition of the great arteries (TGA), and hypoplastic left heart syndrome (HLHS) in a study of apolipoprotein E (APOE) polymorphisms, and neurodevelopmental outcome underwent neurodevelopmental and genetic evaluation at 4 years of age. The domains tested included cognition, language, speech, memory, executive function, visual-motor, fine motor, and reading and math skills. Results: Testing was completed in 178 patients with normal genetic evaluations: VSD (n = 26), TOF (n = 44), TGA (n = 41), and HLHS (n = 67). No differences were found in gestational age, ethnicity, APOE genotype, socioeconomic status, or maternal education among groups. Patient age at the first surgery was significantly lower for patients with TGA and HLHS compared with those with TOF and VSD. The postoperative length of stay was significantly longer for HLHS than all other groups and for TGA compared with TOF and VSD. HLHS correlated significantly with the use of deep hypothermic circulatory arrest and multiple operations. The mean scores for each domain were within normal limits for all groups. Compared with the other patients, those with HLHS had significantly lower scores for cognition, fine motor skills, executive function, and math skills. No significant differences were found among the TGA, TOF or VSD patients for any domain. Significant impairments in at least 1 domain were identified in 8% (2/25) of patients with VSD, 20% (8/41) with TOF, 17% (7/41) with TGA, and 18% (12/65) with HLHS. After correction for the demographic, preoperative, and operative variables, no significant differences were found among the groups for any domain. Conclusions: The mean scores for the neurodevelopmental outcomes domains tested were in the normal range for preschool children with no recognized genetic syndromes after surgery for VSD, TOF, TGA, and HLHS. In each diagnostic group, the number of children with impairments in at least 1 domain increased compared with the general population. Unadjusted neurodevelopmental outcomes for HLHS were lower for cognition, fine motor skills, executive function, and math skills compared with the other patients. After correction for the demographic, preoperative, and operative variables, no significant differences were found among the groups for any domain. The specific cardiac diagnosis determines a large portion of the variation in these covariates. Therefore, although HLHS did predict for poorer outcomes in some domains, it did not add predictive power to the other factors considered.

AB - Objectives: To determine whether a cardiac diagnosis is a predictor of neurodevelopmental outcomes after infant cardiac surgery. Methods: Infants with ventricular septal defect (VSD), tetralogy of Fallot (TOF), transposition of the great arteries (TGA), and hypoplastic left heart syndrome (HLHS) in a study of apolipoprotein E (APOE) polymorphisms, and neurodevelopmental outcome underwent neurodevelopmental and genetic evaluation at 4 years of age. The domains tested included cognition, language, speech, memory, executive function, visual-motor, fine motor, and reading and math skills. Results: Testing was completed in 178 patients with normal genetic evaluations: VSD (n = 26), TOF (n = 44), TGA (n = 41), and HLHS (n = 67). No differences were found in gestational age, ethnicity, APOE genotype, socioeconomic status, or maternal education among groups. Patient age at the first surgery was significantly lower for patients with TGA and HLHS compared with those with TOF and VSD. The postoperative length of stay was significantly longer for HLHS than all other groups and for TGA compared with TOF and VSD. HLHS correlated significantly with the use of deep hypothermic circulatory arrest and multiple operations. The mean scores for each domain were within normal limits for all groups. Compared with the other patients, those with HLHS had significantly lower scores for cognition, fine motor skills, executive function, and math skills. No significant differences were found among the TGA, TOF or VSD patients for any domain. Significant impairments in at least 1 domain were identified in 8% (2/25) of patients with VSD, 20% (8/41) with TOF, 17% (7/41) with TGA, and 18% (12/65) with HLHS. After correction for the demographic, preoperative, and operative variables, no significant differences were found among the groups for any domain. Conclusions: The mean scores for the neurodevelopmental outcomes domains tested were in the normal range for preschool children with no recognized genetic syndromes after surgery for VSD, TOF, TGA, and HLHS. In each diagnostic group, the number of children with impairments in at least 1 domain increased compared with the general population. Unadjusted neurodevelopmental outcomes for HLHS were lower for cognition, fine motor skills, executive function, and math skills compared with the other patients. After correction for the demographic, preoperative, and operative variables, no significant differences were found among the groups for any domain. The specific cardiac diagnosis determines a large portion of the variation in these covariates. Therefore, although HLHS did predict for poorer outcomes in some domains, it did not add predictive power to the other factors considered.

KW - APOE

KW - Apolipoprotein E

KW - Cardiopulmonary bypass

KW - CHD

KW - Congenital heart defect

KW - CPB

KW - Deep hypothermic circulatory arrest

KW - DHCA

KW - GFTA

KW - Goldman Fristoe Test of Articulation 2

KW - HLHS

KW - Hypoplastic left heart syndrome

KW - ND

KW - NEPSY

KW - Neurodevelopmental

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C2 - 20951391

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JO - Journal of Thoracic and Cardiovascular Surgery

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